DataVXACS Applied Nano MaterialsPaper
journal article·2018-05-25

Bioinspired Antimicrobial Nanodots with Amphiphilic and Zwitterionic-like Characteristics for Combating Multidrug-Resistant Bacteria and Biofilm Removal

Hesheng Victor Xu, Xin Ting Zheng, Chao Wang, Yanli Zhao, Yen Nee Tan

ACS Applied Nano Materials· Volume 1· Issue 5
Publisher page
Source abstract

Abstract

Inspired by the natural antimicrobial peptides, we have developed a benign antimicrobial nanodot (BAM dot) via a simple one-step hydrothermal synthesis. The BAM dot possesses the unique properties of both nanoparticles and biomaterials, leading to excellent antibacterial properties with a high therapeutic index. Specifically, this BAM dot has ultrasmall size (3.83 ± 0.73 nm) with a charged neutral surface. They also exhibited amphiphilic and zwitterionic-like properties, which enabled effective bacteria membrane permeabilization, leading to a rapid bactericidal effect and significant biofilm removal. This study opens up new opportunities to design effective bioinspired nanomaterials for combating superbugs against drug resistance and their related applications.
Source: openalex_inverted_index · Quality: baseline

Research context

NanomaterialsBiomaterials

OpenAlex topics: Antimicrobial Peptides and Activities · Carbon and Quantum Dots Applications · Graphene and Nanomaterials Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Institute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), 2 Fusionopolis Way, Singapore 138634, Singapore

Division of Chemical and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore

Division of Cellular and Molecular Research, National Cancer Centre Singapore, 11 Hospital Drive, Singapore 169610, Singapore

Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Singapore

Funding

Institute of Materials Research and Engineering

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