Modular Porous Polymer-Based Microcapsules for Trapping and Near-Infrared Light-Triggered Killing of Bacteria via Gold Nanorods

High Resolution Image Download MS PowerPoint Slide Due to the increasing occurrence of antibiotic-resistant bacterial strains worldwide, there is an urgent need for developing antibiotic-independent strategies to combat bacterial infections. In this study, we developed a modular approach for trapping, retaining, and killing bacteria by means of porous, poly(lactic- co -glycolic acid) (PLGA)-based microcapsules with integrated gold nanorods (AuNRs). AuNRs were coated with thiol-functionalized PLGA beforehand to ensure efficient integration into the hydrophobic microcapsule shells. For the efficient generation of AuNR-functionalized microcapsules, we designed and developed a fast and reliable one-pot bulk emulsification production method. When exposing the AuNR-decorated microcapsules to near-infrared light, both motile and nonmotile bacteria were killed in a highly localized manner due to AuNR-generated heat. Importantly, fibroblast cell viability tests performed with AuNR-decorated microcapsules revealed good biocompatibility of the system. Such a modular antibacterial system can be employed in various applications, including, but not limited to, implant coatings, flushing solutions, and sewage treatment.