DataVXACS Applied Nano MaterialsPaper
journal article·2024-08-23

Ligand Substitution of UiO-66-2OH for Universal Phosphate Detection

Jiansen Wang, Yihong Zhang, Yuting Wang, Qi Sun, Hui Wei

ACS Applied Nano Materials· Volume 7· Issue 16
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Source abstract

Abstract

Phosphate plays a crucial role in biological metabolism across both plants and animals, with abnormal concentrations often indicating various diseases. Despite the prevalence of the molybdenum blue detection method, certain issues persist, including difficulties in preservation and the need for fresh preparation. Here, we introduce a hydroxy-modified metal–organic framework, University of Oslo 66 (UiO-66-2OH), as a versatile platform for fluorescence probes capable of detecting phosphate concentrations in both botanical and clinical contexts. By changing modulator amounts and metal centers, we synthesized particles of varying sizes and active centers (Zr and Hf). Our investigations revealed that a 300 nm UiO-66-2OH particle with a Zr center was optimal for phosphate detection, achieving a limit of detection of 7 μM with low cost. Furthermore, we explored the potential agricultural and diagnostic applications. These findings underscored the versatility and promise of UiO-66-2OH as a sensing material for diverse biological and medical applications.
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Research context

OpenAlex topics: Advanced Nanomaterials in Catalysis · Metal-Organic Frameworks: Synthesis and Applications · Polyoxometalates: Synthesis and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

College of Engineering and Applied Sciences, Nanjing National Laboratory of Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials, Nanjing University, Nanjing, Jiangsu 210023, China

School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu 210023, China

State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing, Jiangsu 210023, China

Funding

Jiangsu Provincial Key Research and Development Program · National Key Research and Development Program of China · Fundamental Research Funds for the Central Universities · National Natural Science Foundation of China · Priority Academic Program Development of Jiangsu Higher Education Institutions · State Key Laboratory of Analytical Chemistry for Life Science · NMPA Key Laboratory for Biomedical Optics

References (29)

Show source-provided references
1. 10.1021/bi00336a00110.1021/bi00336a001 ↗
2. 10.1111/j.1399-3054.1994.tb02539.x10.1111/j.1399-3054.1994.tb02539.x ↗
3. 10.1016/S0968-0004(00)89061-110.1016/S0968-0004(00)89061-1 ↗
4. 10.1104/pp.111.17523210.1104/pp.111.175232 ↗
5. 10.1104/pp.116.2.44710.1104/pp.116.2.447 ↗
6. 10.1016/S2213-8587(19)30426-710.1016/S2213-8587(19)30426-7 ↗
7. 10.1016/S0140-6736(97)10535-910.1016/S0140-6736(97)10535-9 ↗
8. 10.1016/S0140-6736(11)60178-510.1016/S0140-6736(11)60178-5 ↗
9. 10.1016/0003-2697(69)90372-810.1016/0003-2697(69)90372-8 ↗
10. 10.1016/j.talanta.2006.06.01110.1016/j.talanta.2006.06.011 ↗
11. 10.1039/C9AN02215E10.1039/C9AN02215E ↗
12. 10.1093/clinchem/41.4.60910.1093/clinchem/41.4.609 ↗
13. 10.1016/j.watres.2019.11488310.1016/j.watres.2019.114883 ↗
14. 10.1038/s41378-019-0096-810.1038/s41378-019-0096-8 ↗
15. 10.1016/j.apsusc.2018.08.09210.1016/j.apsusc.2018.08.092 ↗
16. 10.1016/j.bios.2016.12.02510.1016/j.bios.2016.12.025 ↗
17. 10.1021/acs.analchem.8b0242810.1021/acs.analchem.8b02428 ↗
18. 10.1007/s00604-022-05311-810.1007/s00604-022-05311-8 ↗
19. 10.1016/j.biosx.2022.10020410.1016/j.biosx.2022.100204 ↗
20. 10.1021/ja805795310.1021/ja8057953 ↗
21. 10.1016/j.mtchem.2018.12.00410.1016/j.mtchem.2018.12.004 ↗
22. 10.1016/j.cej.2021.13405010.1016/j.cej.2021.134050 ↗
23. 10.1038/s41563-023-01541-010.1038/s41563-023-01541-0 ↗
24. 10.1038/s41467-022-28344-210.1038/s41467-022-28344-2 ↗
25. 10.1038/s41467-023-42833-y10.1038/s41467-023-42833-y ↗
26. 10.1016/S0007-1935(17)35239-910.1016/S0007-1935(17)35239-9 ↗
27. 10.1111/nph.1583310.1111/nph.15833 ↗
28. 10.1038/ki.2008.13010.1038/ki.2008.130 ↗
29. 10.1002/adma.20170430310.1002/adma.201704303 ↗