Hyaluronic Acid-Functionalized Dendritic Mesoporous Silica Loaded with Selenium Nanoparticles for In Vivo Elimination of Localized Inflammation
Source abstract
Abstract
Excess reactive oxygen species (ROS) are major contributors to localized inflammation. Therefore, the development of effective ROS scavengers in pro-inflammatory immune cells was an important strategy for the treatment of localized inflammation. In this study, dendritic mesoporous silica nanoparticles (DMSNs) were loaded with selenium nanoparticles (SeNPs) and then functionalized with hyaluronic acid (HA) to enable the targeted delivery of SeNPs. The constructed SeNPs@DMSNs-HA effectively scavenged ROS in macrophages and realized therapeutic effects for localized inflammatory injuries by eliminating the ROS.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Skin Protection and Aging · Polydiacetylene-based materials and applications · Curcumin's Biomedical Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Hubei Key Laboratory of Selenium Resource Research and Biological Application
Hubei Minzu University
Funding
National Natural Science Foundation of China · Hubei Key Laboratory of Selenium Resource Research and Biological Application · Selenium Engineering Technology Plan Project of Enshi
References (23)
Show source-provided references
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