Quaternized Silk Fibroin Nanocarriers Loaded with Chlorin e6 for Photodynamic Elimination of Drug-Resistant Bacteria and Biofilms
Source abstract
Abstract
The increasing prevalence of multidrug-resistant (MDR) bacteria primarily due to the emergence of drug-resistant biofilms that have rendered current antimicrobial agents ineffective poses a significant concern in public health. Therefore, innovative antimicrobial agents need to be urgently developed. This study aimed to design a photodynamic antimicrobial nanocomposite (Ce6/HSF) based on chitosan quaternary ammonium salt (HTCC)-functionalized silk fibroin (SF) loaded with chlorin e6 (Ce6) for eliminating drug-resistant biofilms and bacteria. The prepared Ce6/HSF had low toxicity, good biocompatibility, and excellent ability to generate single-linear-state oxygen. In addition, Ce6/HSF can enter multidrug-resistant bacteria by electrostatic adsorption due to its small size and cationic nature. Furthermore, it effectively promoted wound healing in mice infected with MDR Staphylococcus aureus .
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Silk-based biomaterials and applications · Antimicrobial Peptides and Activities · Nanoplatforms for cancer theranostics
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
School of Biological and Food Engineering, Anhui Polytechnic University, Wuhu, Anhui 241000, People’s Republic of China
State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RADX), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, Jiangsu 215123, People’s Republic of China
Funding
Anhui Polytechnic University · Wannan Medical College · Anhui Provincial Department of Science and Technology · Anhui Provincial Higher Education Institutes
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