DataVXACS Applied Nano MaterialsPaper
journal article·2024-01-26

Two-Dimensional Ti3C2@Porphyridium Nanobiohybrids with Self-Oxygenation Capability for Enhanced Hypoxic Photodynamic Therapy

Tiankun Hui, Ming Gao, Fei Kuang, Youchang Liu, Bingxin Zheng, Liangmin Yu, Meng Qiu, Bin Yue

ACS Applied Nano Materials· Volume 7· Issue 2
Publisher page
Source abstract

Abstract

Hypoxia is one of the inherent characteristics of most solid tumors; the oxygen-dependent (O 2 ) nature of photodynamic therapy (PDT) limits its clinical treatment against hypoxia tumors. Therefore, improving the oxygen partial pressure of hypoxic tumors is of great significance to improve the PDT effect. Herein, we synthesized the Ti 3 C 2 @Porphyridium nanobiohybrids (MX@Pr) by electrostatic self-assembly of photosynthetic oxygen-producing Porphyridium (Pr) and photosensitizer two-dimensional Ti 3 C 2 (MX). Upon 660 nm laser irradiation, MX@Pr in the tumor region could increase the local oxygen level by in situ oxygen generation via Pr-mediated photosynthesis. The oxygen produced by Pr can receive the energy transferred by the excited photosensitizer MX to produce singlet oxygen ( 1 O 2 ), thus significantly enhancing the PDT efficacy of hypoxic tumors and inhibiting tumor growth. This study provides a PDT composite system, which shows the promising prospect of microbial nanomaterial composite systems in the field of biomedicine.
Source: openalex_inverted_index · Quality: baseline

Research context

NanomaterialsComposites

OpenAlex topics: Nanoplatforms for cancer theranostics · MXene and MAX Phase Materials · Photodynamic Therapy Research Studies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Orthopedic Oncology, The Affiliated Hospital of Qingdao University, Qingdao 266000, P. R. China

Central Laboratories, Qingdao Municipal Hospital, Qingdao 266011, P. R. China

Key Laboratory of Marine Chemistry Theory and Technology, Ocean University of China, Qingdao 266100, P. R. China

College of Life Sciences, Qingdao University, Qingdao 266071, P. R. China

Qingdao Institute of Textile Fibre Supervision and Inspection, Qingdao 266061, P. R. China

Funding

Taishan Scholar Project of Shandong Province · Fundamental Research Funds for the Central Universities · National Natural Science Foundation of China · Natural Science Foundation of Shandong Province

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