DataVXACS Applied Nano MaterialsPaper
journal article·2023-11-24

Multifunctional Cellulose Nanofibrils–GdF3 Nanoparticles Hybrid Gel and Its Potential Uses for Drug Delivery and Magnetic Resonance Imaging

Xuehe Jiang, J. Benedikt Mietner, Dhanya Raveendran, Kirill V. Ovchinnikov, Benedikt Sochor, Susanne Mueller, Philipp Boehm-Sturm, Frédéric Lerouge, Frédéric Chaput, Pavel Gurikov, Stephan V. Roth, Julien R. G. Navarro

ACS Applied Nano Materials· Volume 6· Issue 22
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Source abstract

Abstract

A multifunctional hybrid gel based on cellulose nanofibrils (CNFs) was developed by grafting on its surface stearyl acrylate (PSA) and gadolinium(III) fluoride nanoparticles (GdF 3 NPs) via Cu 0 -mediated surface-initiated radical polymerization (SET-LRP) while encapsulating antimicrobial peptides in it. GdF 3 NPs were first surface-modified with 11-phosphonoundecyl acrylate (PDA) to participate in the SET-LRP and cross-linked the grafted polymer-modified CNF. Several characterizations of the hybrid material (GdF 3 –PSA-CNF) were carried out, such as Fourier transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA), rheology, and microscopic analyses. The grafted PSA and cross-linked GdF 3 NPs created sophisticated networks in the CNF-based gel, presenting outstanding rheological properties and promising three-dimensional (3D) printability of this hybrid material (GdF 3 –PSA-CNF). The nanostructures of GdF 3 NPs and their incorporated CNF species were characterized via small-angle X-ray scattering (SAXS). In addition, due to the unique intrinsic property of the GdF 3 nanoparticles, properties for magnetic resonance imaging (MRI) of GdF 3 –PSA-CNF were investigated, showing the potential application as a contrast agent. Finally, the encapsulation of the antimicrobial peptides added another function to the hybrid material, evaluated by an antimicrobial test against methicillin-resistant Staphylococcus aureus (MRSA) in vitro .
Source: openalex_inverted_index · Quality: baseline

Research context

PolymersNanomaterials

OpenAlex topics: Advanced Cellulose Research Studies · Electrospun Nanofibers in Biomedical Applications · Electrohydrodynamics and Fluid Dynamics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Institute of Wood Science, University Hamburg, Leuschnerstraße 91, 21031 Hamburg, Germany

Faculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, 1433 Ås, Norway

Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607 Hamburg, Germany

Charité 3R | Replace, Reduce, Refine, Charité − Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, 10117 Berlin, Germany

Department of Experimental Neurology and Center for Stroke Research, Charité − Universitätsmedizin Berlin, 10117 Berlin, Germany

NeuroCure Cluster of Excellence and Charité Core Facility 7T Experimental MRIs, Charité − Universitätsmedizin Berlin, 10117 Berlin, Germany

Université de Lyon, Ecole Normale Supérieure de Lyon, CNRS UMR 5182, Université Lyon 1, Laboratoire de Chimie, 46 Allée d’Italie, F69364 Lyon, France

Laboratory for Development and Modelling of Novel Nanoporous Materials, Hamburg University of Technology, Eißendorfer Straße 38, 21073 Hamburg, Germany

KTH Royal Institute of Technology, Department of Fibre and Polymer Technology, Teknikringen 56-58, 10044 Stockholm, Sweden

Funding

Bundesministerium f?r Bildung und Forschung · Deutsche Forschungsgemeinschaft · Fachagentur Nachwachsende Rohstoffe

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