Neutrophil Membrane-Coated Mesoporous Silica Nanoparticles Loaded with Hydrocortisone Alleviate DSS-Induced Colitis in Mice

Guozhen Wang; Yongshuai Qi; Jia Xu; Yun Huang; Feng Xiong; Weichang Huang; Xiaoxin Ma; Shuanghu Wang; Changxiong Wang; Yunfang Zhou; Lisheng Wang

doi:10.1021/acsanm.2c04615

journal article·2023-02-24

Neutrophil Membrane-Coated Mesoporous Silica Nanoparticles Loaded with Hydrocortisone Alleviate DSS-Induced Colitis in Mice

Guozhen Wang, Yongshuai Qi, Jia Xu, Yun Huang, Feng Xiong, Weichang Huang, Xiaoxin Ma, Shuanghu Wang, Changxiong Wang, Yunfang Zhou, Lisheng Wang

ACS Applied Nano Materials· Volume 6· Issue 4

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Source abstract

Abstract

The incidence and prevalence of ulcerative colitis (UC) are increasing worldwide. Hydrocortisone enema (HC) is widely used in UC treatment; however, this approach is limited by the easy degradation of HC in the intestinal environment and low intestinal uptake efficiency. Accordingly, the development of methods to improve the targeting efficiency of corticosteroids is an important issue. Mesoporous silica nanoparticles (MSN) and biomimetic nanovesicles (derived from the natural cell membrane structure) provide a basis for improved drug delivery and uptake. In this research, we constructed neutrophil membrane-coated MSN loaded with HC for the treatment of UC. MSN-HC and neutrophil-derived membrane nanoparticles (MSN-HC@NM NPs) were obtained by mechanical extrusion and characterized. The effects of free HC, MSN, MSN-HC, and MSN-HC@NM NPs were compared using dextran sodium sulfate (DSS)-induced colitis model, including terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assays and inflammatory factors in colon tissues. The MSN-HC@NM NPs alleviated DSS-induced colitis by reducing colon apoptosis and ameliorating the destruction of the colonic barrier and inflammation in mice. This research provides a hydrocortisone delivery system with good biosafety and the potential for clinical translation.

Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Inflammatory Bowel Disease · Microscopic Colitis · Nanoparticle-Based Drug Delivery

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Gastroenterology, Shenzhen People’s Hospital, The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen, Guangdong 518020, China

Department of Nuclear Medicine, Nanfang Hospital of Southern Medical University, Guangzhou 510515, China

The Laboratory of Clinical Pharmacy, The Sixth Affiliated Hospital of Wenzhou Medical University, The People’s Hospital of Lishui, Lishui, Zhejiang 323000, China

Depatment of General Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China

School of Pharmaceutical Science, Guangdong Provincial Key Laboratory of New Drug Screening, Southern Medical University, Guangzhou 510515, China

Department of Gastroenterology, Lishui Hospital of Traditional Chinese Medicine, Lishui, Zhejiang 323000, China

Funding

Science, Technology and Innovation Commission of Shenzhen Municipality · National Natural Science Foundation of China · Joint Funds for the innovation of science and Technology,Fujian province · Key Research and Development Project of Lishui

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