journal article·2022-12-23

Controlling Differentiation of Adult Stem Cells Via Cell-Derived Nanoparticles: Implications in Bone Repair

Shruthi Polla Ravi, Yasmeen Shamiya, Aishik Chakraborty, Ali Coyle, Alap Ali Zahid, Jin Wang, Michael S. H. Boutilier, Emmanuel A. Ho, Arghya Paul

ACS Applied Nano Materials· Volume 5· Issue 12
Publisher page

Abstract

Current nanostructured biomaterials-based drug delivery vehicles for bone regeneration applications often show suboptimal cellular uptake and inferior drug loading. To overcome these challenges, we have developed a biomimetic cell-derived nanoparticle (CDN) loaded with the Food and Drug Administration-approved small-molecule therapeutic Dexamethasone, to induce osteogenic differentiation in human adipose-derived stem cells. The drug-loaded CDNs were cytocompatible, maintained hydrodynamic stability with uniform spherical shape and size, and exhibited high-percentage drug loading along with rapid cellular uptake and stem cell differentiation. These results demonstrate for the first time the preparation of Dexamethasone-loaded CDNs capable of directing stem cell fate for advanced bone regeneration applications.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Graphene and Nanomaterials Applications · 3D Printing in Biomedical Research · Nanoparticle-Based Drug Delivery

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Biomedical Engineering, The University of Western Ontario, London, ON N6A 5B9, Canada

Department of Chemistry, The University of Western Ontario, London, ON N6A 5B9, Canada

Department of Chemical and Biochemical Engineering, The University of Western Ontario, London, ON N6A 5B9, Canada

School of Pharmacy, Faculty of Science, University of Waterloo, 10 Victoria St S, Kitchener, ON N2G 1C5, Canada

Waterloo Institute for Nanotechnology, University of Waterloo, 200 University Ave West, Waterloo, ON N2L3G1, Canada

Funding

Canadian Institutes of Health Research · Western University · Canada Research Chairs · Natural Sciences and Engineering Research Council of Canada · Canada Research Coordinating Committee · Government of Ontario

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