Quatsomes Formulated with l-Prolinol-Derived Surfactants as Antibacterial Nanocarriers of (+)-Usnic Acid with Antioxidant Activity
Source abstract
Abstract
The efficacy of the treatment of bacterial infection is seriously reduced because of antibiotic resistance; thus, therapeutic solutions against drug-resistant microbes are necessary. Nanoparticle-based solutions are particularly promising for meeting this challenge because they can offer intrinsic antimicrobial activity and sustained drug release at the target site. Herein, we present a newly developed nanovesicle system of the quatsome family, composed of l-prolinol-derived surfactants and cholesterol, which has noticeable antibacterial activity even on Gram-negative strains, demonstrating great potential for the treatment of bacterial infections. We optimized the vesicle stability and antibacterial activity by tuning the surfactant chain length and headgroup charge (cationic or zwitterionic) and show that these quatsomes can furthermore serve as nanocarriers of pharmaceutical actives, demonstrated here by the encapsulation of (+)-usnic acid, a natural substance with many pharmacological properties.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Lichen and fungal ecology · Microbial Natural Products and Biosynthesis · Bryophyte Studies and Records
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Dipartimento di Scienze Fisiche e Chimiche, Università degli Studi dell’Aquila, Via Vetoio, 67010 Coppito, L’Aquila, Italy
Institut de Ciència de Materials de Barcelona (ICMAB-CSIC), Esfera Universitat Autónoma de Barcelona (UAB); Campus UAB s/n, E-08193 Cerdanyola del Vallès, Spain
Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Campus Universitari de Bellaterra, E-08193 Cerdanyola, Spain
Dipartimento di Scienze Cliniche Applicate e Biotecnologie, Università degli Studi dell’Aquila, Via Vetoio, 67010 Coppito, L’Aquila, Italy
Dipartimento di Chimica, Università di Roma “Sapienza”, Piazzale Aldo Moro 5, 00185 Roma, Italy
Funding
Ministerio de Economía y Competitividad · H2020 Marie Sklodowska-Curie Actions · Generalitat de Catalunya
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