Enhanced radiosensitivity and chemoradiation efficacy in nasopharyngeal carcinoma via a dual-targeted SPION@polymer hybrid nanosensitizer
Source abstract
Abstract
Abstract Cisplatin-based nanoparticles show good potential in enhancing the effect of nasopharynx carcinoma (NPC) therapy but are still limited by their low radiation sensitization and poor tumor targeting ability. Herein, an ingenious design of multifunctional superparamagnetic iron oxide nanoparticle (SPION)@polymer hybrid nanosensitizer (SPHN) with enhanced radiosensitization and dual-targeting capability is described. SPHN have a core-shell structure, in which radiosensitizer superparamagnetic iron oxide particle (SPION) and cis-platinum (CDDP) are encapsulated in RGD-conjugated amphiphilic block copolymers. These unique structures endow SPHN with outstanding radiosensitization and tumor targeting abilities. When combined with X-rays, SPHN showed strong promotion of the apoptosis of CNE-1 cells in vitro. In addition, RNA-seq and KEGG enrichment analyses indicated that the PI3K-Akt and TNF signaling pathways were closely related to the molecular mechanism of SPHN in chemoradiotherapy. Furthermore, gene set enrichment analysis (GSEA) revealed that SPHN + X-rays treatment decreased translation initiation pathways and the cytoplasmic translation pathway. Through a combination of radiation and chemotherapy, SPHN can achieve remarkable inhibition of tumor growth in vivo, making this nanotechnology a general platform for the chemoradiation therapy of NPC in the future.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Nanoparticle-Based Drug Delivery · Nanoplatforms for cancer theranostics · Advanced Nanomaterials in Catalysis
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (31)
Show source-provided references
1. Chen, Y. P. et al. Nasopharyngeal carcinoma. Lancet 394, 64–80 (2019).10.1016/S0140-6736(19)30956-0 ↗
2. Chua, M. L. K., Wee, J. T. S., Hui, E. P. & Chan, A. T. C. Nasopharyngeal carcinoma. Lancet 387, 1012–1024 (2016).10.1016/S0140-6736(15)00055-0 ↗
3. Blanchard, P. et al. Chemotherapy and radiotherapy in nasopharyngeal carcinoma: an update of the MAC-NPC meta-analysis. Lancet Oncol. 16, 645–655 (2015).10.1016/S1470-2045(15)70126-9 ↗
4. Chen, Y. P. et al. Chemotherapy in combination with radiotherapy for definitive-intent treatment of stage II-IVA nasopharyngeal carcinoma: CSCO and ASCO guideline. J. Clin. Oncol. 39, 840–859 (2021).10.1200/JCO.20.03237 ↗
5. Chen, L. et al. Concurrent chemoradiotherapy plus adjuvant chemotherapy versus concurrent chemoradiotherapy alone in patients with locoregionally advanced nasopharyngeal carcinoma: a phase 3 multicentre randomised controlled trial. Lancet Oncol. 13, 163–171 (2012).10.1016/S1470-2045(11)70320-5 ↗
6. Shi, J., Kantoff, P. W., Wooster, R. & Farokhzad, O. C. Cancer nanomedicine: progress, challenges and opportunities. Nat. Rev. Cancer 17, 20–37 (2017).10.1038/nrc.2016.108 ↗
7. Sun, Y. et al. Induction chemotherapy plus concurrent chemoradiotherapy versus concurrent chemoradiotherapy alone in locoregionally advanced nasopharyngeal carcinoma: a phase 3, multicentre, randomised controlled trial. Lancet Oncol. 17, 1509–1520 (2016).10.1016/S1470-2045(16)30410-7 ↗
8. Ding, Y. et al. Platinum-crosslinking polymeric nanoparticle for synergetic chemoradiotherapy of nasopharyngeal carcinoma. Bioact. Mater. 6, 4707–4716 (2021).
9. Ding, Y. et al. Investigating the EPR effect of nanomedicines in human renal tumors via ex vivo perfusion strategy. Nano Today 35, 100970 (2020).10.1016/j.nantod.2020.100970 ↗
10. Xiao, X. et al. Self-targeting platinum (IV) amphiphilic prodrug nano-assembly as radiosensitizer for synergistic and safe chemoradiotherapy of hepatocellular carcinoma. Biomaterials 289, 121793 (2022).10.1016/j.biomaterials.2022.121793 ↗
11. Song, G. et al. Carbon-coated FeCo nanoparticles as sensitive magnetic-particle-imaging tracers with photothermal and magnetothermal properties. Nat. Biomed. Eng. 4, 325–334 (2020).10.1038/s41551-019-0506-0 ↗
12. Xiao, Y. & Du, J. Superparamagnetic nanoparticles for biomedical applications. J. Mater. Chem. B 8, 354–367 (2020).10.1039/C9TB01955C ↗
13. Pan, Y., Du, X., Zhao, F. & Xu, B. Magnetic nanoparticles for the manipulation of proteins and cells. Chem. Soc. Rev. 41, 2912–2942 (2012).10.1039/c2cs15315g ↗
14. Xu, C. & Sun, S. New forms of superparamagnetic nanoparticles for biomedical applications. Adv. Drug Deliv. Rev. 65, 732–743 (2013).10.1016/j.addr.2012.10.008 ↗
15. Gao, J., Gu, H. & Xu, B. Multifunctional magnetic nanoparticles: design, synthesis, and biomedical applications. Acc. Chem. Res. 42, 1097–1107 (2009).10.1021/ar9000026 ↗
16. Hu, Y., Mignani, S., Majoral, J. P., Shen, M. & Shi, X. Construction of iron oxide nanoparticle-based hybrid platforms for tumor imaging and therapy. Chem. Soc. Rev. 47, 1874–1900 (2018).10.1039/C7CS00657H ↗
17. Tian, X. et al. Functional magnetic hybrid nanomaterials for biomedical diagnosis and treatment. Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol. 10, e1476 (2018).10.1002/wnan.1476 ↗
18. Song, G., Cheng, L., Chao, Y., Yang, K. & Liu, Z. Emerging nanotechnology and advanced materials for cancer radiation therapy. Adv. Mater. 29, 1700996 (2017).10.1002/adma.201700996 ↗
19. Wu, J. et al. Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes (II). Chem. Soc. Rev. 48, 1004–1076 (2019).10.1039/C8CS00457A ↗
20. Deng, Y. et al. Facile preparation of hybrid core-shell nanorods for photothermal and radiation combined therapy. Nanoscale 8, 3895–3899 (2016).10.1039/C5NR09102K ↗
21. Chen, Q. et al. Nanoparticle-enhanced radiotherapy to trigger robust cancer immunotherapy. Adv. Mater. 31, 1802228 (2019).10.1002/adma.201802228 ↗
22. Huang, G. et al. Superparamagnetic iron oxide nanoparticles: amplifying ROS stress to improve anticancer drug efficacy. Theranostics 3, 116–126 (2013).10.7150/thno.5411 ↗
23. Wei, H. & Wang, E. Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes. Chem. Soc. Rev. 42, 6060–6093 (2013).10.1039/c3cs35486e ↗
24. Hauser, A. K. et al. Targeted iron oxide nanoparticles for the enhancement of radiation therapy. Biomaterials 105, 127–135 (2016).10.1016/j.biomaterials.2016.07.032 ↗
25. Ding, Z. et al. Furin‐controlled Fe3O4 nanoparticle aggregation and 19F signal “turn‐on” for precise MR imaging of tumors. Adv. Funct. Mater. 29, 1903860 (2019).10.1002/adfm.201903860 ↗
26. Zhu, J. et al. Facile synthesis of magnetic core-shell nanocomposites for MRI and CT bimodal imaging. J. Mater. Chem. B 3, 6905–6910 (2015).10.1039/C5TB00775E ↗
27. Ding, Y., Zeng, L., Xiao, X., Chen, T. & Pan, Y. Multifunctional magnetic nanoagents for bioimaging and therapy. ACS Appl. Bio Mater. 4, 1066–1076 (2021).10.1021/acsabm.0c01099 ↗
28. Du, X., Zhou, J., Shi, J. & Xu, B. Supramolecular hydrogelators and hydrogels: from soft matter to molecular biomaterials. Chem. Rev. 115, 13165–13307 (2015).10.1021/acs.chemrev.5b00299 ↗
29. Kim, D., Kim, J., Park, Y. I., Lee, N. & Hyeon, T. Recent development of inorganic nanoparticles for biomedical imaging. ACS Cent. Sci. 4, 324–336 (2018).10.1021/acscentsci.7b00574 ↗
30. Shi, J., Votruba, A., Farokhzad, O. & Langer, R. Nanotechnology in drug delivery and tissue engineering: from discovery to applications. Nano Lett. 10, 3223–3230 (2010).10.1021/nl102184c ↗
31. Li, X. et al. Mimetic heat shock protein mediated immune process to enhance cancer immunotherapy. Nano Lett. 20, 4454–4463 (2020).10.1021/acs.nanolett.0c01230 ↗