Graphene-electrode array for brain map remodeling of the cortical surface
Source abstract
Abstract
Abstract Cortical maps, which are indicative of cognitive status, are shaped by the organism’s experience. Previous mapping tools, such as penetrating electrodes and imaging techniques, are limited in their ability to be used to assess high-resolution brain maps largely owing to their invasiveness and poor spatiotemporal resolution, respectively. In this study, we developed a flexible graphene-based multichannel electrode array for electrocorticography (ECoG) recording, which enabled us to assess cortical maps in a time- and labor-efficient manner. The flexible electrode array, formed by chemical vapor deposition (CVD)-grown graphene, provided low impedance and electrical noise because a good interface between the graphene and brain tissue was created, which improved the detectability of neural signals. Furthermore, cortical map remodeling was induced upon electrical stimulation at the cortical surface through a subset of graphene spots. This result demonstrated the macroscale plasticity of cortical maps, suggesting perceptual enhancement via electrical rehabilitation at the cortical surface.
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Research context
OpenAlex topics: Neuroscience and Neural Engineering · Neural dynamics and brain function · Advanced Memory and Neural Computing
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (45)
Show source-provided references
1. Feldman, D. E. Synaptic mechanisms for plasticity in neocortex. Annu. Rev. Neurosci. 32, 33–55 (2009).10.1146/annurev.neuro.051508.135516 ↗
2. Tao, H. W., Li, Y. T. & Zhang, L. I. Formation of excitation-inhibition balance: inhibition listens and changes its tune. Trends Neurosci. 37, 528–530 (2014).10.1016/j.tins.2014.09.001 ↗
3. Williamson, R. S., Hancock, K. E., Shinn-Cunningham, B. G. & Polley, D. B. Locomotion and Task Demands Differentially Modulate Thalamic Audiovisual Processing during Active Search. Curr. Biol. 25, 1885–1891 (2015).10.1016/j.cub.2015.05.045 ↗
4. Hensch, T. K. Critical period plasticity in local cortical circuits. Nat. Rev. Neurosci. 6, 877–888 (2005).10.1038/nrn1787 ↗
5. Yang, S., Weiner, B. D., Zhang, L. S., Cho, S. J. & Bao, S. Homeostatic plasticity drives tinnitus perception in an animal model. Proc. Natl Acad. Sci. USA. 108, 14974–14979 (2011).10.1073/pnas.1107998108 ↗
6. Espinosa, J. S. & Stryker, M. P. Development and plasticity of the primary visual cortex. Neuron 75, 230–249 (2012).10.1016/j.neuron.2012.06.009 ↗
7. Han, Y. K., Kover, H., Insanally, M. N., Semerdjian, J. H. & Bao, S. Early experience impairs perceptual discrimination. Nat. Neurosci. 10, 1191–1197 (2007).10.1038/nn1941 ↗
8. Yang, S., Zhang, L. S., Gibboni, R., Weiner, B. & Bao, S. Impaired development and competitive refinement of the cortical frequency map in tumor necrosis factor-α-deficient mice. Cereb. Cortex 24, 1956–1965 (2014).10.1093/cercor/bht053 ↗
9. Masri, S. et al. Blast Exposure Disrupts the Tonotopic Frequency Map in the Primary Auditory Cortex. Neuroscience 379, 428–434 (2018).10.1016/j.neuroscience.2018.03.041 ↗
10. Barkat, T. R., Polley, D. B. & Hensch, T. K. A critical period for auditory thalamocortical connectivity. Nat. Neurosci. 14, 1189–1194 (2011).10.1038/nn.2882 ↗
11. Buonomano, D. V. & Merzenich, M. M. Cortical plasticity: from synapses to maps. Annu. Rev. Neurosci. 21, 149–186 (1998).10.1146/annurev.neuro.21.1.149 ↗
12. Yang, S., Zhang, L. S., Gibboni, R., Weiner, B. & Bao, S. Impaired development and competitive refinement of the cortical frequency map in tumor necrosis factor-alpha-deficient mice. Cereb. Cortex 24, 1956–1965 (2014).10.1093/cercor/bht053 ↗
13. Stensaas, S. S. & Stensaas, L. J. Histopathological evaluation of materials implanted in the cerebral cortex. Acta Neuropathol. 41, 145–155 (1978).10.1007/BF00689766 ↗
14. Hofmeijer, J. C. et al. Detecting Cortical Spreading Depolarization with Full Band Scalp Electroencephalography: An Illusion? Front. Neurol. 9, 17 (2018).10.3389/fneur.2018.00017 ↗
15. Dreier, J. P. et al. Recording, analysis, and interpretation of spreading depolarizations in neurointensive care: Review and recommendations of the COSBID research group. J. Cereb. Blood Flow. Metab. 37, 1595–1625 (2017).10.1177/0271678X16654496 ↗
16. Rickard, T. C. et al. The calculating brain: an fMRI study. Neuropsychologia 38, 325–335 (2000).10.1016/S0028-3932(99)00068-8 ↗
17. Deneux, T. et al. Accurate spike estimation from noisy calcium signals for ultrafast three-dimensional imaging of large neuronal populations in vivo. Nat. Commun. 7, 12190 (2016).10.1038/ncomms12190 ↗
18. Lee, J. H. et al. Global and local fMRI signals driven by neurons defined optogenetically by type and wiring. Nature 465, 788–792 (2010).10.1038/nature09108 ↗
19. Park, D. W. et al. Graphene-based carbon-layered electrode array technology for neural imaging and optogenetic applications. Nat. Commun. 5, 5258 (2014).10.1038/ncomms6258 ↗
20. Kuzum, D. et al. Transparent and flexible low noise graphene electrodes for simultaneous electrophysiology and neuroimaging. Nat. Commun. 5, 5259 (2014).10.1038/ncomms6259 ↗
21. Viventi, J. et al. Flexible, foldable, actively multiplexed, high-density electrode array for mapping brain activity in vivo. Nat. Neurosci. 14, 1599–1605 (2011).10.1038/nn.2973 ↗
22. Masvidal-Codina, E. et al. High-resolution mapping of infraslow cortical brain activity enabled by graphene microtransistors. Nat. Mater. 18, 280–288 (2019).10.1038/s41563-018-0249-4 ↗
23. Blaschke, B. M. et al. Mapping brain activity with flexible graphene micro-transistors. 2d Mater. 4, 025040 (2017).10.1088/2053-1583/aa5eff ↗
24. Park, S.-W. et al. Epidural Electrotherapy for Epilepsy. Small 14, e1801732 (2018).10.1002/smll.201801732 ↗
25. Lian, J., Bikson, M., Sciortino, C., Stacey, W. C. & Durand, D. M. Local suppression of epileptiform activity by electrical stimulation in rat hippocampus in vitro. J. Physiol. 547, 427–434 (2013).10.1113/jphysiol.2002.033209 ↗
26. Jensen, A. L. & Durand, D. M. Suppression of axonal conduction by sinusoidal stimulation in rat hippocampus in vitro. J. Neural Eng. 4, 1–16 (2007).10.1088/1741-2560/4/2/001 ↗
27. Brown, S. P. & Hestrin, S. Intracortical circuits of pyramidal neurons reflect their long-range axonal targets. Nature 457, 1133–1136 (2009).10.1038/nature07658 ↗
28. Spruston, N. Pyramidal neurons: dendritic structure and synaptic integration. Nat. Rev. Neurosci. 9, 206–221 (2008).10.1038/nrn2286 ↗
29. Petrus, E. et al. Crossmodal induction of thalamocortical potentiation leads to enhanced information processing in the auditory cortex. Neuron 81, 664–673 (2014).10.1016/j.neuron.2013.11.023 ↗
30. Oswald, A. M. & Reyes, A. D. Maturation of intrinsic and synaptic properties of layer 2/3 pyramidal neurons in mouse auditory cortex. J. Neurophysiol. 99, 2998–3008 (2008).10.1152/jn.01160.2007 ↗
31. Chen, X. et al. Encoding and retrieval of artificial visuoauditory memory traces in the auditory cortex requires the entorhinal cortex. J. Neurosci. 33, 9963–9974 (2013).10.1523/JNEUROSCI.4078-12.2013 ↗
32. Beierholm, U. R. et al. Bayesian priors are encoded independently from likelihoods in human multisensory perception. J. Vis. 9, 21–29 (2009).10.1167/9.5.23 ↗
33. Kampa, B. M., Letzkus, J. J. & Stuart, G. J. Cortical feed-forward networks for binding different streams of sensory information. Nat. Neurosci. 9, 1472–1473 (2006).10.1038/nn1798 ↗
34. Kozloski, J., Hamzei-Sichani, F. & Yuste, R. Stereotyped position of local synaptic targets in neocortex. Science 293, 868–872 (2001).10.1126/science.293.5531.868 ↗
35. Kilgard, M. P. & Merzenich, M. M. Cortical map reorganization enabled by nucleus basalis activity. Science 279, 1714–1718 (1998).10.1126/science.279.5357.1714 ↗
36. Weinberger, N. M. Specific long-term memory traces in primary auditory cortex. Nat. Rev. Neurosci. 5, 279–290 (2004).10.1038/nrn1366 ↗
37. Yu, A. J. & Dayan, P. Uncertainty, neuromodulation, and attention. Neuron 46, 681–692 (2005).10.1016/j.neuron.2005.04.026 ↗
38. Froemke, R. C., Merzenich, M. M. & Schreiner, C. E. A synaptic memory trace for cortical receptive field plasticity. Nature 450, 425–429 (2007).10.1038/nature06289 ↗
39. Sarter, M., Hasselmo, M. E., Bruno, J. P. & Givens, B. Unraveling the attentional functions of cortical cholinergic inputs: interactions between signal-driven and cognitive modulation of signal detection. Brain Res. Brain Res. Rev. 48, 98–111 (2005).10.1016/j.brainresrev.2004.08.006 ↗
40. Malenka, R. C. & Bear, M. F. LTP and LTD: an embarrassment of riches. Neuron 44, 5–21 (2004).10.1016/j.neuron.2004.09.012 ↗
41. Froemke, R. C. Plasticity of cortical excitatory-inhibitory balance. Annu. Rev. Neurosci. 38, 195–219 (2015).10.1146/annurev-neuro-071714-034002 ↗
42. Blundon, J. A. & Zakharenko, S. S. Presynaptic gating of postsynaptic synaptic plasticity: a plasticity filter in the adult auditory cortex. Neuroscientist 19, 465–478 (2013).10.1177/1073858413482983 ↗
43. Bao, S., Chan, V. T. & Merzenich, M. M. Cortical remodelling induced by activity of ventral tegmental dopamine neurons. Nature 412, 79–83 (2001).10.1038/35083586 ↗
44. Miyakawa, A. et al. Tinnitus Correlates with Downregulation of Cortical Glutamate Decarboxylase 65 Expression But Not Auditory Cortical Map Reorganization. J. Neurosci. 39, 9989–10001 (2019).10.1523/JNEUROSCI.1117-19.2019 ↗
45. Yang, S., Su, W. & Bao, S. Long-term, but not transient, threshold shifts alter the morphology and increase the excitability of cortical pyramidal neurons. J. Neurophysiol. 108, 1567–1574 (2012).10.1152/jn.00371.2012 ↗