In vivo high-efficiency targeted photodynamic therapy of ultra-small Fe3O4@polymer-NPO/PEG-Glc@Ce6 nanoprobes based on small size effect
Source abstract
Abstract
Effectively prolonging the residence time of nanoprobes in the tumor region and reducing the accumulation of nanoprobes in the vital organs (for example, lung, liver and spleen) is crucial for high-efficiency photodynamic therapy (PDT) of cancer. Herein, we systematically report an ultra-small and highly stable nanoplatform with diameters of 4, 8 and 13 nm that exhibited excellent photodynamic therapeutic efficacy using Fe3O4@polymer-NPO/PEG-Glc@Ce6 nanoprobes. Based on the small size effect, the nanoprobes displayed lower cytotoxicity and excellent biocompatibility. Owing to the synergistic virtues of markedly active targeting and intrinsic small size effect, the Fe3O4@P-NPO/PEG-Glc@Ce6 nanoprobes can effectively prolong their residence time in the tumor region and reduce accumulation in the normal organs. Benefitting from the small size effect, the synthesized Fe3O4@P-NPO/PEG-Glc@Ce6 nanoprobes exhibited excellent tumor-targeting capability and photodynamic therapeutic efficacy by inhibiting the growth of tumors in mice under visible red light irradiation with a relatively lower power. The successful application of the small size effect in Fe3O4@P-NPO/PEG-Glc@Ce6 nanoprobes to significantly improve the PDT efficiency in our strategy suggests new building blocks for PDT of tumors and paves a new way for clinical therapies and translation in the near future. Ultrasmall nanoparticles that dwell longer in the vicinity of cancer cells and are safer than conventional nanoparticles have been created. Photodynamic therapy seeks to destroy viruses and diseased cells by attaching nanoparticles to them and then heating the nanoparticles using laser light. Guo Gao from Shanghai Jiao Tong University in China and colleagues have engineered biocompatible nanoparticles that spend more time near tumors and accumulate less in healthy organs. They made iron oxide nanoparticles that were functionalized with PEGylated glucose, dendrimers and a photosensitizer called Ce6 and had diameters as small as four nanometers. Tests on mice demonstrated the nanoparticle's low cytotoxicity and excellent biocompatibility. The researchers attribute the benefits of these nanoparticles to their small size and propose that the strategy could be used to improve the efficacy of photodynamic therapy. Photodynamic therapy is a promising and effective strategy for being trialed for clinical application. However, poor targeting accumulation of traditional nanoprobes in tumor tissues has hindered its clinical use. Herein, ultra-small and highly stable Fe3O4@P-NPO/PEG-Glc@Ce6 nanoprobes were developed to improve the tumor-targeting efficiency and photodynamic therapeutic efficacy based on small size effect. The nanoprobes effectively prolong the residence time in the tumor region, reduce the accumulation in vital organs and significantly inhibit the growth of tumors in vivo. The successful application of small size effect in nanoprobes provides a new path for clinical therapies and translation in the near future.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · Photodynamic Therapy Research Studies · Biosensors and Analytical Detection
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (54)
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