Controlled synthesis of a core-shell nanohybrid for effective multimodal image-guided combined photothermal/photodynamic therapy of tumors
Source abstract
Abstract
Abstract In this paper, a simple strategy is proposed to prepare a core-shell nanohybrid (PB@PCN) by the controllable coating of zirconium-porphyrin (PCN) shells on Prussian blue (PB) nanoparticles. By adjusting the thickness of the PCN shell, the PB@PCN nanohybrid with the best comprehensive performance was obtained for tumor treatment and imaging. The integrated nanosystem as a tandem catalyst is able to convert H2O2 to O2 through the PB core, and then the O2 is directly injected into the PCN framework, leading to a high quantum yield of singlet oxygen to kill tumor cells and attack heat shock proteins (HSPs). The nanohybrid was further camouflaged by a tumor cell membrane (PB@PCN@MEM) with good immune evasion and active targeting ability. Upon accumulation at the tumor site, PN@PCN@MEM showed an enhanced photodynamic therapeutic effect against hypoxic tumor cells. Furthermore, coupled with the photothermal therapy of PB, photothermal/photodynamic synergistic therapy of tumors can be realized. In addition, due to its excellent imaging performance, this core-shell nanohybrid can be employed for the multimodal image-guided therapy of tumors.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · Extracellular vesicles in disease · Advanced Nanomaterials in Catalysis
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (39)
Show source-provided references
1. Park, J., Jiang, Q., Feng, D., Mao, L. & Zhou, H. C. Size-controlled synthesis of porphyrinic metal-organic framework and functionalization for targeted photodynamic therapy. J. Am. Chem. Soc. 138, 3518–3525 (2016).10.1021/jacs.6b00007 ↗
2. Song, G., Cheng, L., Chao, Y., Yang, K. & Liu, Z. Emerging nanotechnology and advanced materials for cancer radiation therapy. Adv. Mater. 29, 1700996 (2017).10.1002/adma.201700996 ↗
3. Fan, W., Yung, B., Huang, P. & Chen, X. Nanotechnology for multimodal synergistic cancer therapy. Chem. Rev. 117, 13566–13638 (2017).10.1021/acs.chemrev.7b00258 ↗
4. Shi, J., Kantoff, P. W., Wooster, R. & Farokhzad, O. C. Cancer nanomedicine: progress, challenges and opportunities. Nat. Rev. Cancer 17, 20–37 (2017).10.1038/nrc.2016.108 ↗
5. Pi, F. et al. Nanoparticle orientation to control RNA loading and ligand display on extracellular vesicles for cancer regression. Nat. Nanotechnol. 13, 82–89 (2018).10.1038/s41565-017-0012-z ↗
6. He, X. Y. et al. Functional polymer/inorganic hybrid nanoparticles for macrophage targeting delivery of oligodeoxynucleotides in cancer immunotherapy. Mater. Today Chem. 4, 106–116 (2017).10.1016/j.mtchem.2017.01.006 ↗
7. Zhu, X. et al. Upconversion nanocomposite for programming combination cancer therapy by precise control of microscopic temperature. Nat. Commun. 9, 2176 (2018).10.1038/s41467-018-04571-4 ↗
8. Wang, S. et al. H. A facile one-pot synthesis of a two-dimensional MoS2 /Bi2S3 composite theranostic nanosystem for multi-modality tumor imaging and therapy. Adv. Mater. 27, 2775–2782 (2015).10.1002/adma.201500870 ↗
9. He, X. et al. Redox-active AIEgen-derived plasmonic and fluorescent core@shell nanoparticles for multimodality bioimaging. J. Am. Chem. Soc. 140, 6904–6911 (2018).10.1021/jacs.8b02350 ↗
10. Wang, H. et al. A biomimetic hybrid nanoplatform for encapsulation and precisely controlled delivery of theranostic agents. Nat. Commun. 6, 10081 (2015).10.1038/ncomms10081 ↗
11. Yang, Q. et al. Regulating the spatial distribution of metal nanoparticles within metal-organic frameworks to enhance catalytic efficiency. Nat. Commun. 8, 14429 (2017).10.1038/ncomms14429 ↗
12. Zhang, W. et al. Mesoporous metal-organic frameworks with size-, shape-, and space-distribution-controlled pore structure. Adv. Mater. 27, 2923–2929 (2015).10.1002/adma.201405752 ↗
13. Ma, X. et al. Single gold-bridged nanoprobes for identification of single point DNA mutations. Nat. Commun. 10, 836 (2019).10.1038/s41467-019-08769-y ↗
14. Lu, G. et al. Imparting functionality to a metal-organic framework material by controlled nanoparticle encapsulation. Nat. Chem. 4, 310–316 (2012).10.1038/nchem.1272 ↗
15. Bin, D. S. et al. Controlling the compositional chemistry in single nanoparticles for functional hollow carbon nanospheres. J. Am. Chem. Soc. 139, 13492–13498 (2017).10.1021/jacs.7b07027 ↗
16. Gai, S. et al. Recent advances in functional nanomaterials for light–triggered cancer therapy. Nano Today 19, 146–187 (2018).10.1016/j.nantod.2018.02.010 ↗
17. Qi, J. et al. Light-driven transformable optical agent with adaptive functions for boosting cancer surgery outcomes. Nat. Commun. 9, 1848 (2018).10.1038/s41467-018-04222-8 ↗
18. Chechetka, S. A. et al. Light-driven liquid metal nanotransformers for biomedical theranostics. Nat. Commun. 8, 15432 (2017).10.1038/ncomms15432 ↗
19. Yu, X. et al. CT/MRI-guided synergistic radiotherapy and X-ray inducible photodynamic therapy using Tb-doped Gd-W-nanoscintillators. Angew. Chem. Int. Ed. 58, 2017–2022 (2019).10.1002/anie.201812272 ↗
20. Ni, D. et al. Magnetic targeting of nanotheranostics enhances cerenkov radiation-induced photodynamic therapy. J. Am. Chem. Soc. 140, 14971–14979 (2018).10.1021/jacs.8b09374 ↗
21. Zhu, H., Cheng, P., Chen, P. & Pu, K. Recent progress in the development of near-infrared organic photothermal and photodynamic nanotherapeutics. Biomater. Sci. 6, 746–765 (2018).10.1039/C7BM01210A ↗
22. Guo, W., Guo, C., Zheng, N., Sun, T. & Liu, S. Csx WO3 nanorods coated with polyelectrolyte multilayers as a multifunctional nanomaterial for bimodal imaging-guided photothermal/photodynamic cancer treatment. Adv. Mater. 29, 1604157 (2017).10.1002/adma.201604157 ↗
23. Cai, Y. et al. Diketopyrrolopyrrole-triphenylamine organic nanoparticles as multifunctional reagents for photoacoustic imaging-guided photodynamic/photothermal synergistic tumor therapy. ACS Nano. 11, 1054–1063 (2017).10.1021/acsnano.6b07927 ↗
24. Goel, S. et al. Activatable hybrid nanotheranostics for tetramodal imaging and synergistic photothermal/photodynamic therapy. Adv. Mater. 30, 1704367 (2018).10.1002/adma.201704367 ↗
25. Liu, Y. et al. Modulating hypoxia via nanomaterials chemistry for efficient treatment of solid tumors. Acc. Chem. Res. 51, 2502–2511 (2018).10.1021/acs.accounts.8b00214 ↗
26. Yang, G. et al. Hollow MnO2 as a tumor-microenvironment-responsive biodegradable nano-platform for combination therapy favoring antitumor immune responses. Nat. Commun. 8, 902 (2017).10.1038/s41467-017-01050-0 ↗
27. Liu, W. L. et al. Aggressive man-made red blood cells for hypoxia-resistant photodynamic therapy. Adv. Mater. 30, e1802006 (2018).10.1002/adma.201802006 ↗
28. Kim, J. et al. Continuous O2-evolving MnFe2O4 nanoparticle-anchored mesoporous silica nanoparticles for efficient photodynamic therapy in hypoxic cancer. J. Am. Chem. Soc. 139, 10992–10995 (2017).10.1021/jacs.7b05559 ↗
29. Lan, G. et al. Nanoscale metal-organic framework overcomes hypoxia for photodynamic therapy primed cancer immunotherapy. J. Am. Chem. Soc. 140, 5670–5673 (2018).10.1021/jacs.8b01072 ↗
30. Chen, W. H. et al. Overcoming the heat endurance of tumor cells by interfering with the anaerobic glycolysis metabolism for improved photothermal therapy. ACS Nano. 11, 1419–1431 (2017).10.1021/acsnano.6b06658 ↗
31. Chu, K. F. & Dupuy, D. E. Thermal ablation of tumours: biological mechanisms and advances in therapy. Nat. Rev. Cancer 14, 199–208 (2014).10.1038/nrc3672 ↗
32. Yang, Y. et al. 1D Coordination polymer nanofibers for low-temperature photothermal therapy. Adv. Mater. 29, 199 (2017).
33. Li, S. Y. et al. Cancer cell membrane camouflaged cascade bioreactor for cancer targeted starvation and photodynamic therapy. ACS Nano. 11, 7006–7018 (2017).10.1021/acsnano.7b02533 ↗
34. Xie, W. et al. Cancer cell membrane camouflaged nanoparticles to realize starvation therapy together with checkpoint blockades for enhancing cancer therapy. ACS Nano. 13, 2849–2857 (2019).10.1021/acsnano.8b03788 ↗
35. Parodi, A. et al. Synthetic nanoparticles functionalized with biomimetic leukocyte membranes possess cell-like functions. Nat. Nanotechnol. 8, 61–68 (2013).10.1038/nnano.2012.212 ↗
36. Tang, Z. et al. Pyroelectric nanoplatform for NIR-II-triggered photothermal therapy with simultaneous pyroelectric dynamic therapy. Mater. Horiz. 5, 946–952 (2018).10.1039/C8MH00627J ↗
37. Chen, H., Tian, J., He, W. & Guo, Z. H2O2-activatable and O2-evolving nanoparticles for highly efficient and selective photodynamic therapy against hypoxic tumor cells. J. Am. Chem. Soc. 137, 1539–1547 (2015).10.1021/ja511420n ↗
38. Liu, Y. et al. One-dimensional Fe2P acts as a fenton agent in response to NIR II light and ultrasound for deep tumor synergetic theranostics. Angew. Chem. Int. Ed. 58, 2407–2412 (2019).10.1002/anie.201813702 ↗
39. Liu, Y., Bhattarai, P., Dai, Z. & Chen, X. Photothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer. Chem. Soc. Rev. 48, 2053–2108 (2019).10.1039/C8CS00618K ↗