Mussel-inspired thermo-switchable underwater adhesive based on a Janus hydrogel
Source abstract
Abstract
Abstract On-demand underwater adhesives with excellent adhesive and gentle detachment properties enable stable connections to various biomedical devices and biointerfaces and avoid the risk of harmful tissue damage upon detachment. Herein, we present a Janus hydrogel adhesive that can reversibly switch its adhesion strength, which is controlled by temperature, using a thermoresponsive polymer and mussel-inspired molecules. This thermoswitchable adhesive (TSA) hydrogel displays both strong adhesion and gentle detachment with an over 1000-fold gap in underwater adhesion strength onto glass, titanium, aluminum, and Teflon substrates when exposed to temperatures above and below the lower critical solution temperature (LCST). The adhesion switch is possibly caused by the change in toughness of the TSA hydrogels with temperature because the Janus hydrogel possesses gradient crosslinked structures. Moreover, the lowermost surface is sufficiently soft to gently detach from the substrate below the LCST. The electrode-integrated hydrogel remains on human skin, and electrical signals are continuous over 10 min above the LCST. In contrast, commercially available hydrogel electrodes quickly swell and detach from the skin. The thermoswitchability of the TSA hydrogel, with its robust adhesion and gentle detachment, offers significant potential for biomedical applications characterized by minimally invasive procedures.
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Research context
OpenAlex topics: Polymer Surface Interaction Studies · Advanced Sensor and Energy Harvesting Materials · Surface Modification and Superhydrophobicity
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (61)
Show source-provided references
1. Wu, S. J. & Zhao, X. Bioadhesive technology platforms. Chem. Rev. 123, 14084–14118 (2023).10.1021/acs.chemrev.3c00380 ↗
2. Fan, H. & Gong, J. P. Bioinspired underwater adhesives. Adv. Mater. 33, 2102983 (2021).10.1002/adma.202102983 ↗
3. Lee, C. et al. Bioinspired materials for underwater adhesion with pathways to switchability. Cell Rep. Phys. Sci. 4, 101597 (2023).
4. Chatterjee, B., Mohseni, P. & Sen, S. Bioelectronic sensor nodes for the internet of bodies. Annu. Rev. Biomed. Eng. 25, 101–129 (2023).10.1146/annurev-bioeng-110220-112448 ↗
5. Jiang, Y. et al. Wireless, closed-loop, smart bandage with integrated sensors and stimulators for advanced wound care and accelerated healing. Nat. Biotechnol. 41, 652–662 (2023).10.1038/s41587-022-01528-3 ↗
6. Kusama, S. et al. Transdermal electroosmotic flow generated by a porous microneedle array patch. Nat. Commun. 12, 658 (2021).10.1038/s41467-021-20948-4 ↗
7. Guo, J. et al. Engineering multifunctional bioadhesive powders through dynamic metal-ligand coordination. Sci. China Chem. 65, 2260–2273 (2022).10.1007/s11426-022-1345-3 ↗
8. Wu, S. J., Yuk, H., Wu, J., Nabzdyk, C. S. & Zhao, X. A multifunctional origami patch for minimally invasive tissue sealing. Adv. Mater. 33, 2007667 (2021).10.1002/adma.202007667 ↗
9. Zhao, Y. et al. Bio-inspired reversible underwater adhesive. Nat. Commun. 8, 2218 (2017).
10. Yu, Z. & Wu, P. Underwater communication and optical camouflage ionogels. Adv. Mater. 33, 2008479 (2021).10.1002/adma.202008479 ↗
11. Cui, C. & Liu, W. Recent advances in wet adhesives: adhesion mechanism, design principle and applications. Prog. Polym. Sci. 116, 101388 (2021).10.1016/j.progpolymsci.2021.101388 ↗
12. Cui, C. et al. Water‐triggered hyperbranched polymer universal adhesives: from strong underwater adhesion to rapid sealing hemostasis. Adv. Mater. 31, 1905761 (2019).
13. Cui, C. et al. A janus hydrogel wet adhesive for internal tissue repair and anti‐postoperative adhesion. Adv. Funct. Mater. 30, 2005689 (2020).
14. Xue, B. et al. Hydrogel tapes for fault-tolerant strong wet adhesion. Nat. Commun. 12, 7156 (2021).10.1038/s41467-021-27529-5 ↗
15. Yuen, H. Y., Bei, H. P. & Zhao, X. Underwater and wet adhesion strategies for hydrogels in biomedical applications. Chem. Eng. J. 431, 133372 (2022).10.1016/j.cej.2021.133372 ↗
16. Li, J. et al. Tough adhesives for diverse wet surfaces. Science 357, 378–381 (2017).10.1126/science.aah6362 ↗
17. Fan, H. & Gong, J. P. Fabrication of bioinspired hydrogels: challenges and opportunities. Macromolecules 53, 2769–2782 (2020).10.1021/acs.macromol.0c00238 ↗
18. Fan, H., Wang, J. & Gong, J. P. Barnacle cement proteins‐inspired tough hydrogels with robust, long‐lasting, and repeatable underwater adhesion. Adv. Funct. Mater. 31, 2009334 (2021).10.1002/adfm.202009334 ↗
19. Chen, X., Mizuta, R., Fukata, N. & Taguchi, T. Design of bio-inspired adhesive surface composed of hexanoyl group-modified gelatin and silicon nanowire. Colloids Surf. B Biointerfaces 178, 111–119 (2019).10.1016/j.colsurfb.2019.02.053 ↗
20. Shafiq, Z. et al. Bioinspired underwater bonding and debonding on demand. Angew. Chem. 124, 4408–4411 (2012).10.1002/ange.201108629 ↗
21. Li, S. et al. Dytiscus lapponicus—inspired structure with high adhesion in dry and underwater environments. ACS Appl Mater. Interfaces 13, 42287–42296 (2021).10.1021/acsami.1c13604 ↗
22. Baik, S. et al. A wet-tolerant adhesive patch inspired by protuberances in suction cups of octopi. Nature 546, 396–400 (2017).10.1038/nature22382 ↗
23. Xue, L. et al. Hybrid surface patterns mimicking the design of the adhesive toe pad of tree frog. ACS Nano 11, 9711–9719 (2017).10.1021/acsnano.7b04994 ↗
24. Sandoval, J. A., Jadhav, S., Quan, H., Deheyn, D. D. & Tolley, M. T. Reversible adhesion to rough surfaces both in and out of water, inspired by the clingfish suction disc. Bioinspir. Biomim. 14, 066016 (2019).10.1088/1748-3190/ab47d1 ↗
25. Waite, J. H. Mussel power. Nat. Mater. 7, 8–9 (2008).10.1038/nmat2087 ↗
26. Waite, J. H. Nature’s underwater adhesive specialist. Int. J. Adhes. Adhes. 7, 9–14 (1987).10.1016/0143-7496(87)90048-0 ↗
27. Abe, H. et al. S/N Co-doped hollow carbon particles for oxygen reduction electrocatalysts prepared by spontaneous polymerization at oil–water interfaces. ACS Omega 5, 18391–18396 (2020).10.1021/acsomega.0c02182 ↗
28. Lee, H., Scherer, N. F. & Messersmith, P. B. Single-molecule mechanics of mussel adhesion. Proc. Natl Acad. Sci. USA 103, 12999–13003 (2006).10.1073/pnas.0605552103 ↗
29. Lee, H., Dellatore, S. M., Miller, W. M. & Messersmith, P. B. Mussel-inspired surface chemistry for multifunctional coatings. Science 318, 426–430 (2007).10.1126/science.1147241 ↗
30. Cheng, B. et al. Ultrastrong underwater adhesion on diverse substrates using non-canonical phenolic groups. Nat. Commun. 13, 1892 (2022).
31. Sivasundarampillai, J. et al. A strong quick-release biointerface in mussels mediated by serotonergic cilia-based adhesion. Science 382, 829–834 (2023).10.1126/science.adi7401 ↗
32. Lee, B. P., Messersmith, P. B., Israelachvili, J. N. & Waite, J. H. Mussel-inspired adhesives and coatings. Annu. Rev. Mater. Res 41, 99–132 (2011).10.1146/annurev-matsci-062910-100429 ↗
33. Wang, S. et al. Bio‐inspired adhesive with reset‐on demand, reuse‐many (RORM) modes. Adv. Funct. Mater. 33, 2215064 (2023).
34. Wu, J. et al. Mussel-inspired chemistry for robust and surface-modifiable multilayer films. Langmuir 27, 13684–13691 (2011).10.1021/la2027237 ↗
35. Ahn, B. K., Lee, D. W., Israelachvili, J. N. & Waite, J. H. Surface-initiated self-healing of polymers in aqueous media. Nat. Mater. 13, 867–872 (2014).10.1038/nmat4037 ↗
36. Lee, J. N., Lee, S. Y. & Park, W. H. Bioinspired self-healable polyallylamine-based hydrogels for wet adhesion: synergistic contributions of catechol-amino functionalities and nanosilicate. ACS Appl Mater. Interfaces 13, 18324–18337 (2021).10.1021/acsami.1c02141 ↗
37. Xie, C., Wang, X., He, H., Ding, Y. & Lu, X. Mussel‐inspired hydrogels for self‐adhesive bioelectronics. Adv. Funct. Mater. 30, 1909954 (2020).10.1002/adfm.201909954 ↗
38. Wang, Z. et al. Facile biomimetic self-coacervation of tannic acid and polycation: tough and wide pH range of underwater adhesives. Chem. Eng. J. 404, 127069 (2021).
39. Zhang, C. et al. Dopamine-triggered hydrogels with high transparency, self-adhesion, and thermoresponse as skinlike sensors. ACS Nano 15, 1785–1794 (2021).10.1021/acsnano.0c09577 ↗
40. Westerman, C. R., McGill, B. C. & Wilker, J. J. Sustainably sourced components to generate high-strength adhesives. Nature 621, 306–311 (2023).10.1038/s41586-023-06335-7 ↗
41. Hou, Y. et al. Tuning water-resistant networks in mussel-inspired hydrogels for robust wet tissue and bioelectronic adhesion. ACS Nano 17, 2745–2760 (2023).10.1021/acsnano.2c11053 ↗
42. Shi, X. & Wu, P. A smart patch with on‐demand detachable adhesion for bioelectronics. Small 17, 2101220 (2021).10.1002/smll.202101220 ↗
43. Liang, Y., Xu, H., Li, Z., Zhangji, A. & Guo, B. Bioinspired injectable self-healing hydrogel sealant with fault-tolerant and repeated thermo-responsive adhesion for sutureless post-wound-closure and wound healing. Nanomicro Lett. 14, 185 (2022).
44. Hong, S. et al. Air/water interfacial formation of freestanding, stimuli‐responsive, self‐healing catecholamine janus‐faced microfilms. Adv. Mater. 26, 7581–7587 (2014).10.1002/adma.201403259 ↗
45. Yang, H.-C., Xu, W., Du, Y., Wu, J. & Xu, Z.-K. Composite free-standing films of polydopamine/polyethyleneimine grown at the air/water interface. RSC Adv. 4, 45415–45418 (2014).10.1039/C4RA04549A ↗
46. Abe, H., Nozaki, K., Kumatani, A., Matsue, T. & Yabu, H. N- and Fe-containing carbon films prepared by calcination of polydopamine composites self-assembled at air/water interface for oxygen reduction reaction. Chem. Lett. 48, 102–105 (2019).10.1246/cl.180872 ↗
47. Wang, Y. et al. A phenol‐amine superglue inspired by insect sclerotization process. Adv. Mater. 32, e2002118 (2020).10.1002/adma.202002118 ↗
48. Wang, H. et al. An integrally formed janus hydrogel for robust wet‐tissue adhesive and anti‐postoperative adhesion. Adv. Mater. 35, 2300394 (2023).
49. Abe, H. & Yabu, H. Bio-inspired incrustation interfacial polymerization of dopamine and cross-linking with gelatin toward robust, biodegradable three-dimensional hydrogels. Langmuir 37, 6201–6207 (2021).10.1021/acs.langmuir.1c00364 ↗
50. Coy, E., Iatsunskyi, I., Colmenares, J. C., Kim, Y. & Mrówczyński, R. Polydopamine films with 2D-like layered structure and high mechanical resilience. ACS Appl Mater. Interfaces 13, 23113–23120 (2021).10.1021/acsami.1c02483 ↗
51. Abe, H., Ina, T., Kaji, H. & Nishizawa, M. Mussel-inspired interfacial ultrathin films for cellular adhesion on the wrinkled surfaces of hydrophobic fluids. Polym. J. 55, 1231–1236 (2023).10.1038/s41428-023-00799-0 ↗
52. Abe, H., Matsue, T. & Yabu, H. Reversible shape transformation of ultrathin polydopamine-stabilized droplet. Langmuir 33, 6404–6409 (2017).10.1021/acs.langmuir.7b01355 ↗
53. Alfieri, M. L., Weil, T., Ng, D. Y. W. & Ball, V. Polydopamine at biological interfaces. Adv. Colloid Interface Sci. 305, 102689 (2022).10.1016/j.cis.2022.102689 ↗
54. Ponzio, F. et al. Robust Alginate-Catechol@Polydopamine free-standing membranes obtained from the water/air interface. Langmuir 33, 2420–2426 (2017).10.1021/acs.langmuir.6b04435 ↗
55. Eklund, A., Ikkala, O. & Zhang, H. Highly efficient switchable underwater adhesion in channeled hydrogel networks. Adv. Funct. Mater. https://doi.org/10.1002/adfm.202214091 (2023).10.1002/adfm.202214091 ↗
56. Kim, M. et al. Switchable photonic bio‐adhesive materials. Adv. Mater. 33, 2103674 (2021).
57. Zhang, Z. et al. Design of large-span stick-slip freely switchable hydrogels via dynamic multiscale contact synergy. Nat. Commun. 13, 6964 (2022).
58. Putnam, A. A. & Wilker, J. J. Changing polymer catechol content to generate adhesives for high versus low energy surfaces. Soft Matter 17, 1999–2009 (2021).10.1039/D0SM01944E ↗
59. Wang, Z., Guo, L., Xiao, H., Cong, H. & Wang, S. A reversible underwater glue based on photo- and thermo-responsive dynamic covalent bonds. Mater. Horiz. 7, 282–288 (2020).10.1039/C9MH01148J ↗
60. Maier, G. P., Rapp, M. V., Waite, J. H., Israelachvili, J. N., & Butler, A. Adaptive synergy between catechol and lysine promotes wet adhesion by surface salt displacement. Science 349, 628–632 (2015).10.1126/science.aab0556 ↗
61. Ma, Y. et al. Remote control over underwater dynamic attachment/detachment and locomotion. Adv. Mater. 30, 1801595 (2018).