Dual-responsive disassembly of core-shell nanoparticles with self-supplied H2O2 and autocatalytic Fenton reaction for enhanced chemodynamic therapy
Source abstract
Abstract
Abstract Chemodynamic therapy holds great potential for cancer treatment due to its reliable curative effects, minimal invasiveness, and few systemic side effects. However, the limited amount of intracellular H 2 O 2 makes achieving high-performance chemodynamic therapy challenging. Herein, we report a core-shell nanoplatform with dual-responsive disassembly that self-supplies H 2 O 2 and undergoes an autocatalytic Fenton reaction for enhanced chemodynamic therapy. The platform was designed by coating glucose oxidase-mimicking nanozyme gold nanoparticles (AuNPs) with a metal-polyphenol network (Au@MPN). Both ATP and low pH can disassemble the Au@MPN to release Fe(III), which can then be reduced into Fe(II) by the simultaneously released tannic acid (TA). In particular, the exposed AuNPs can catalyze the oxidation of intracellular glucose to produce H 2 O 2 . Subsequently, Fe(II) and the self-supplied H 2 O 2 induce an efficient Fenton reaction for chemodynamic therapy by generating hydroxyl radicals (•OH) that are highly toxic to cancer cells. Moreover, tumor growth can be effectively suppressed after both intratumoral and intravenous Au@MPN administration. Additionally, metastatic melanoma lung tumors could be inhibited by intratracheal instillation of Au@MPN. Thus, this work not only reports a facile method to construct a chemodynamic agent with self-supplied H 2 O 2 and high therapeutic efficiency but also provides insight into the design of nanoplatforms with enhanced efficiency for chemodynamic therapy.
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Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · Advanced Nanomaterials in Catalysis · Extracellular vesicles in disease
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (37)
Show source-provided references
1. Esteva, A. et al. Dermatologist-level classification of skin cancer with deep neural networks. Nature 542, 115–118 (2017).10.1038/nature21056 ↗
2. Schadendorf, D. et al. Melanoma. Lancet 392, 971–984 (2018).10.1016/S0140-6736(18)31559-9 ↗
3. Formenti, S. C. et al. Radiotherapy induces responses of lung cancer to CTLA-4 blockade. Nat. Med. 24, 1845–1851 (2018).10.1038/s41591-018-0232-2 ↗
4. Haas, L. et al. Acquired resistance to anti-MAPK targeted therapy confers an immune-evasive tumor microenvironment and cross-resistance to immunotherapy in melanoma. Nat. Cancer 2, 693–708 (2021).10.1038/s43018-021-00221-9 ↗
5. Sullivan, R. J. et al. Atezolizumab plus cobimetinib and vemurafenib in BRAF-mutated melanoma patients. Nat. Med. 25, 929–935 (2019).10.1038/s41591-019-0474-7 ↗
6. Chen, Q. et al. In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment. Nat. Nanotechnol. 14, 89–97 (2019).10.1038/s41565-018-0319-4 ↗
7. Li, H. et al. Disrupting tumour vasculature and recruitment of aPDL1-loaded platelets control tumour metastasis. Nat. Commun. 12, 1–10 (2021).10.1038/s41467-020-20314-w ↗
8. Zheng, C. et al. Engineering nano‐therapeutics to boost adoptive cell therapy for cancer treatment. Small Methods 5, 2001191 (2021).10.1002/smtd.202001191 ↗
9. Jiang, W., Wang, Y., Wargo, J. A., Lang, F. F. & Kim, B. Considerations for designing preclinical cancer immune nanomedicine studies. Nat. Nanotechnol. 16, 6–15 (2021).10.1038/s41565-020-00817-9 ↗
10. Tang, Z., Zhao, P., Wang, H., Liu, Y. & Bu, W. Biomedicine meets fenton chemistry. Chem. Rev. 121, 1981–2019 (2021).10.1021/acs.chemrev.0c00977 ↗
11. He, H. et al. Cleavable bimetallic-organic polymers for ROS mediated cascaded cancer therapy under the guidance of MRI through tumor hypoxia relief strategy. Sci. China Chem. 63, 936–945 (2020).10.1007/s11426-020-9735-2 ↗
12. Tang, Z., Liu, Y., He, M. & Bu, W. Chemodynamic therapy: tumour microenvironment-mediated fenton and fenton-like reactions. Angew. Chem. Int. Ed. 58, 946–956 (2019).10.1002/anie.201805664 ↗
13. Liu, Z. et al. GSH-induced chemotaxis nanomotors for cancer treatment by ferroptosis strategy. Sci. China Chem. 65, 989–1002 (2022).10.1007/s11426-021-1208-6 ↗
14. Ma, S. et al. A ROS-responsive aspirin polymeric prodrug for modulation of tumor microenvironment and cancer immunotherapy. CCS Chem. 2, 390–400 (2020).10.31635/ccschem.020.202000140 ↗
15. Cao, R. et al. Protein nanoparticles containing Cu (II) and DOX for efficient chemodynamic therapy via self-generation of H2O2. Chin. Chem. Lett. 31, 3127–3130 (2020).10.1016/j.cclet.2020.06.031 ↗
16. Dang, W. et al. 3D printed bioceramic scaffolds as a universal therapeutic platform for synergistic therapy of osteosarcoma. ACS Appl. Mater. Inter. 13, 18488–18499 (2021).10.1021/acsami.1c00553 ↗
17. Liu, C. et al. An open source and reduce expenditure ROS generation strategy for chemodynamic/photodynamic synergistic therapy. Nat. Commun. 11, 1–9 (2020).10.1038/s41467-019-13993-7 ↗
18. Gao, S. et al. Self-Supply of O2 and H2O2 by a nanocatalytic medicine to enhance combined chemo/chemodynamic therapy. Adv. Sci. 6, 1902137 (2019).10.1002/advs.201902137 ↗
19. Lin, L.-S. et al. Synthesis of copper peroxide nanodots for H2O2 self-supplying chemodynamic therapy. J. Am. Chem. Soc. 141, 9937–9945 (2019).10.1021/jacs.9b03457 ↗
20. Fu, L.-H., Qi, C., Lin, J. & Huang, P. Catalytic chemistry of glucose oxidase in cancer diagnosis and treatment. Chem. Soc. Rev. 47, 6454–6472 (2018).10.1039/C7CS00891K ↗
21. Fu, L. H., Qi, C., Hu, Y. R., Lin, J. & Huang, P. Glucose oxidase-instructed multimodal synergistic cancer therapy. Adv. Mater. 31, 1808325 (2019).10.1002/adma.201808325 ↗
22. Wu, J. et al. Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes (II). Chem. Soc. Rev. 48, 1004–1076 (2019).10.1039/C8CS00457A ↗
23. Jiang, D. et al. Nanozyme: new horizons for responsive biomedical applications. Chem. Soc. Rev. 48, 3683–3704 (2019).10.1039/C8CS00718G ↗
24. Zhang, L. et al. An adenosine triphosphate-responsive autocatalytic fenton nanoparticle for tumor ablation with self-supplied H2O2 and acceleration of Fe (III)/Fe (II) conversion. Nano Lett. 18, 7609–7618 (2018).10.1021/acs.nanolett.8b03178 ↗
25. Ding, Y. et al. A nanomedicine fabricated from gold nanoparticles-decorated metal-organic framework for cascade chemo/chemodynamic cancer therapy. Adv. Sci. 7, 2001060 (2020).10.1002/advs.202001060 ↗
26. Zheng, C., Li, M. & Ding, J. Challenges and opportunities of nanomedicines in clinical translation. BIO Integr. 2, 57–60 (2021).10.15212/bioi-2021-0016 ↗
27. Zhang, H., Liang, X., Han, L. & Li, F. “Non‐Naked” gold with glucose oxidase‐like activity: a nanozyme for tandem catalysis. Small 14, 1803256 (2018).10.1002/smll.201803256 ↗
28. Xu, J. et al. Ultrasmall gold nanoclusters‐enabled fabrication of ultrafine gold aerogels as novel self‐supported nanozymes. Small 18, 2200525 (2022).10.1002/smll.202200525 ↗
29. Guo, Y., Sun, Q., Wu, F. G., Dai, Y. & Chen, X. Polyphenol‐containing nanoparticles: synthesis, properties, and therapeutic delivery. Adv. Mater. 33, 2007356 (2021).10.1002/adma.202007356 ↗
30. Caruso, F., Spasova, M., Salgueiriño‐Maceira, V. & Liz‐Marzán, L. Multilayer assemblies of silica‐encapsulated gold nanoparticles on decomposable colloid templates. Adv. Mater. 13, 1090–1094 (2001).10.1002/1521-4095(200107)13:14<1090::AID-ADMA1090>3.0.CO;2-H ↗
31. Rahim, M. A. et al. Coordination-driven multistep assembly of metal-polyphenol films and capsules. Chem. Mater. 26, 1645–1653 (2014).10.1021/cm403903m ↗
32. Wang, Z. et al. Metal-phenolic-network-coated dendrimer-drug conjugates for tumor mr imaging and chemo/chemodynamic therapy via amplification of endoplasmic reticulum stress. Adv. Mater. 34, 2107009 (2022).10.1002/adma.202107009 ↗
33. Dai, Y. et al. Toxic reactive oxygen species enhanced synergistic combination therapy by self-assembled metal-phenolic network nanoparticles. Adv. Mater. 30, 1704877 (2018).10.1002/adma.201704877 ↗
34. Song, X.-R. et al. Polyphenol-inspired facile construction of smart assemblies for ATP- and pH-responsive tumor MR/optical imaging and photothermal therapy. Small 13, 1603997 (2017).10.1002/smll.201603997 ↗
35. Yan, J. et al. Engineering radiosensitizer-based metal-phenolic networks potentiate STING pathway activation for advanced radiotherapy. Adv. Mater. 34, e2105783 (2022).10.1002/adma.202105783 ↗
36. Zhang, Z. et al. Polyphenol‐based nanomedicine evokes immune activation for combination. Cancer Treat. Angew. Chem. Int. Ed. 60, 1967–1975 (2021).10.1002/anie.202013406 ↗
37. Tian, X. et al. Pulmonary delivery of reactive oxygen species/glutathione-responsive paclitaxel dimeric nanoparticles improved therapeutic indices against metastatic lung cancer. ACS Appl. Mater. Interfaces 13, 56858–56872 (2021).10.1021/acsami.1c16351 ↗