journal article·2021-12Open access

NIR-responsive MXene nanobelts for wound healing

Lin Jin, Xiaoqing Guo, Di Gao, Cui Wu, Bin Hu, Guangxuan Tan, Nannan Du, Xiaolu Cai, Zhe Yang, Xingcai Zhang

NPG Asia Materials· Volume 13· Issue 1

Abstract

Abstract Effectively achieving wound healing is a great challenge. Herein, we facilely prepared temperature-responsive MXene nanobelt fibers (T-RMFs) carrying vitamin E with a controllable release ability for wound healing. These T-RMFs were composed of MXene nanosheets spread along polyacrylonitrile and polyvinylpyrrolidone composite nanobelts together with a thermosensitive PAAV- coating layer. The high mass loading and high surface area of the MXene nanosheets endow the T-RMFs with excellent photothermal properties. The temperature could be easily controlled by near-infrared (NIR) irradiation exposure, and then the thermoresponsive polymeric coating layer relaxed the interface to dissolve vitamin E and promote vitamin E release. The T-RMFs demonstrated excellent biocompatibility and wound-healing functions in cellular and animal tests. The facile method, high mass loading, high surface area, excellent wound-healing functions, interesting nanosheet/nanobelt structure, mass production potential, and NIR responsive properties of these T-RMFs indicate the great potential of our nanobelts for wound healing, tissue engineering, and much broader application areas. This facile nanosheet/nanobelt preparation strategy paves a new way for nanomaterial fabrication and applications.
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Research context

OpenAlex topics: Graphene and Nanomaterials Applications · MXene and MAX Phase Materials · Electrospun Nanofibers in Biomedical Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

References (40)

Show source-provided references
1. Mahmoudi, S. et al. Heterogeneity in old fibroblasts is linked to variability in reprogramming and wound healing. Nature 574, 553–5583 (2019).10.1038/s41586-019-1658-5 ↗
2. Tetley, R. J. et al. Tissue fluidity promotes epithelial wound healing. Nature 15, 1195–1203 (2019).
3. Zhang, X. X. et al. Black phosphorus-loaded separable microneedles as responsive oxygen-delivery carriers for wound jealing. ACS Nano 14, 5901–5908 (2020).10.1021/acsnano.0c01059 ↗
4. Hou, R. et al. Surface-degradable drug-eluting stent with anticoagulation, antiproliferation, and endothelialization functions. Biomolecules 92, 69 (2019).10.3390/biom9020069 ↗
5. Hao, Y. L. et al. Effective wound healing enabled by discrete alternative electric fields from wearable nanogenerators. ACS Nano 12, 12533–12540 (2018).10.1021/acsnano.8b07038 ↗
6. Wang, X. et al. Differentiation of bMSCs on biocompatible, biodegradable, and biomimetic scaffolds for largely defected tissue repair. ACS Appl. Bio Mater. 3, 735–746 (2019).10.1021/acsabm.9b01063 ↗
7. Ouyang, J. et al. In situ sprayed NIR-responsive, analgesic black phosphorus-based gel for diabetic ulcer treatment. Proc. Natl Acad. Sci. USA 117, 28667–28677 (2020).10.1073/pnas.2016268117 ↗
8. Cui, T. T. et al. Large‐scale fabrication of robust artificial skins from a biodegradable sealant‐loaded nanofiber scaffold to skin tissue via microfluidic blow‐spinning. Adv. Mater. 32, 2000982 (2020).10.1002/adma.202000982 ↗
9. Srifa, W. et al. Cas9-AAV6-engineered human mesenchymal stromal cells improved cutaneous wound healing in diabetic mice. Nat. Commun. 11, 2470 (2020).10.1038/s41467-020-16065-3 ↗
10. Stapelfeldt, K. et al. Controlling the multiscale structure of nanofibrous fibrinogen scaffolds for wound healing. Nano Lett. 19, 6554–6563 (2019).10.1021/acs.nanolett.9b02798 ↗
11. Wang, S. Q. et al. Nanoenzyme-reinforced injectable hydrogel for healing diabetic wounds infected with multidrug resistant bacteria. Nano Lett. 20, 5149–5158 (2020).10.1021/acs.nanolett.0c01371 ↗
12. Li, Z. et al. Biomimicry, biomineralization, and bioregeneration of bone using advanced three-dimensional fibrous hydroxyapatite scaffold. Mater. Today Adv. 3, 100014 (2019).10.1016/j.mtadv.2019.100014 ↗
13. Kamaysbayew, V. et al. Covalent surface modifications and superconductivity of two-dimensional metal carbide MXenes. Science 369, 979–983 (2020).10.1126/science.aba8311 ↗
14. Zhao, X. et al. Smart Ti3C2Tx MXene fabric with fast humidity response and joule heating for healthcare and medical therapy applications. ACS Nano 14, 8793–8805 (2020).10.1021/acsnano.0c03391 ↗
15. Li, Z. K. et al. Antibiotics separation with MXene membranes Based on regularly stacked high-aspect-ratio nanosheets. Angew Chem. Int. Ed. 59, 9751–9756 (2020).10.1002/anie.202002935 ↗
16. Xu, D. X., Li, Z. D., Li, L. S. & Wang, J. Insights into the photothermal conversion of 2D MXene nanomaterials: synthesis, mechanism, and applications. Adv. Funct. Mater. 30, 2000712 (2020).10.1002/adfm.202000712 ↗
17. Wang, C. D., Chen, S. M. & Song, L. Tuning 2D MXenes by surface controlling and interlayer engineering: methods, properties, and synchrotron radiation characterizations. Adv. Funct. Mater. 30, 2000869 (2020).10.1002/adfm.202000869 ↗
18. Shin, W. E. H. et al. Large-scale wet-spinning of highly electroconductive MXene fibers. Nat. Commun. 11, 2825 (2020).10.1038/s41467-020-16671-1 ↗
19. Lao, J. C. et al. Electricity generation based on a photothermally driven Ti3C2Tx MXene nanofluidic water pump. Nano Energy 70, 104481 (2020).10.1016/j.nanoen.2020.104481 ↗
20. Gao, D. et al. Multifunctional phototheranostic nanomedicine for cancer imaging and treatment. Mater. Today Bio 5, 100035 (2020).10.1016/j.mtbio.2019.100035 ↗
21. Pan, S. S. et al. 2D MXene‐integrated 3D‐printing scaffolds for augmented osteosarcoma phototherapy and accelerated tissue reconstruction. Adv. Sci. 7, 1901511 (2020).10.1002/advs.201901511 ↗
22. Gao, Y. Y. et al. Microchannel‐confined MXene based flexible piezoresistive multifunctional micro‐force sensor. Adv. Funct. Mater. 30, 1909603 (2020).10.1002/adfm.201909603 ↗
23. Liao, H., Guo, X. L., Wan, P. B. & Yu, G. H. Conductive MXene nanocomposite organohydrogel for flexible, healable, low‐temperature tolerant strain sensors. Adv. Funct. Mater. 29, 19040507 (2019).
24. Xia, Y. et al. Thickness-independent capacitance of vertically aligned liquid-crystalline MXenes. Nature 557, 409–412 (2018).10.1038/s41586-018-0109-z ↗
25. Yang, Z. et al. Fighting immune cold and reprogramming immunosuppressive tumor microenvironment with red blood cell membrane-camouflaged nanobullets. ACS Nano 14, 17442–17457 (2020).10.1021/acsnano.0c07721 ↗
26. Huang, R. et al. MXene composite nanofibers for cell culture and tissue engineering. ACS Appl. Bio Mater. 3, 2125–2131 (2020).10.1021/acsabm.0c00007 ↗
27. Jin, L. et al. Synergistic effects of electrical stimulation and aligned nanofibrous microenvironment on growth behaviour of mesenchymal stem cells. ACS Appl. Mater. Interfaces 10, 18543–18550 (2018).10.1021/acsami.8b04136 ↗
28. Jin, L. et al. Fabrication and characterization of three-dimensional (3D) core-shell structure nanofibers designed for 3D dynamic cell culture. ACS Appl. Mater. Interfaces 9, 17718–17726 (2017).10.1021/acsami.7b02126 ↗
29. Li, X. X. et al. Self‐healing microsupercapacitors with size‐dependent 2D MXene. Adv. Mater. 7, 821–829 (2020).
30. Shen, J. et al. 2D MXene nanofilms with tunable gas transport channels. Adv. Funct. Mater. 28, 1801511 (2018).10.1002/adfm.201801511 ↗
31. Umrao, S. et al. MXene artificial muscles based on ionically cross-linked Ti3C2Tx electrode for kinetic soft robotics. Sci. Robot. 4, 7797 (2019).10.1126/scirobotics.aaw7797 ↗
32. Parekh, G., Shi, Y., Zheng, J., Zhang, X. & Leporatti, S. Nano-carriers for targeted delivery and biomedical imaging enhancement. Ther. Deliv. 9, 451 (2018).10.4155/tde-2018-0013 ↗
33. Gong, Z. et al. Composite nanomaterial thin film-based biosensors. SENSORS, 2010 IEEE, 29–32 (2010).
34. Han, F. et al. Triple-synergistic 2D material-based dual-delivery antibiotic platform. NPG Asia Mater. 12, 15 (2020).10.1038/s41427-020-0195-x ↗
35. Yang, J. et al. Biologically modified nanoparticles as theranostic bionanomaterials. Prog. Mater. Sci. 100768 (2020).10.1016/j.pmatsci.2020.100768 ↗
36. Li, J., Li, Z., Chu, D., Jin, L. & Zhang, X. Fabrication and biocompatibility of core–shell structured magnetic fibrous scaffold. J. Biomed. Nanotechnol. 15, 500–506 (2019).10.1166/jbn.2019.2701 ↗
37. Tang, Z. et al. A materials-science perspective on tackling COVID-19. Nat. Rev. Mater. 26, 458 (2020).
38. Zhou, M. et al. pH-sensitive poly (β-amino ester) s nanocarriers facilitate the inhibition of drug resistance in breast cancer cells. Nanomaterials 8, 952 (2018).10.3390/nano8110952 ↗
39. Tang, Z. et al. Insights from nanotechnology in COVID-19 treatment. Nano Today 36, 101019 (2020).10.1016/j.nantod.2020.101019 ↗
40. Mai, W. et al. A versatile bottom-up interface self-assembly strategy to hairy nanoparticle-based 2D monolayered composite and functional nanosheets. Chem. Comm. 55, 10241 (2019).10.1039/C9CC04664J ↗