Nano-formulated curcumin accelerates acute wound healing through Dkk-1-mediated fibroblast mobilization and MCP-1-mediated anti-inflammation
Source abstract
Abstract
Schematic illustration of nanoformulated curcumin accelerates wound healing. (a) Curcumin nanoformulation through electrospinning greatly enhances its solubility. (b) Topically applied Curcumin/Gelatin nanofibrous mat releases bioactive curcumin to mobilize wound site fibroblasts by enhancing both cell proliferation and migration, a process partially mediated by Dickkopf-related protein-1-regulated Wnt/β-catenin pathway signaling. In the mean time, fibroblasts decreased the expression of monocyte chemoattractant protein-1, leading to lasting inhibition of inflammatory response during the healing process. As a result, wound environment turns out to be more in favor of physiological healing, with faster re-epithelialization, granulation tissue formation, as well as collagen deposition and matuaration from proliferative fibroblasts.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Wound Healing and Treatments · Curcumin's Biomedical Applications · Natural Fiber Reinforced Composites
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (40)
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