V₂CT_x MXene Nanosheets as Enhanced Free-Radical Scavengers for Alleviating Oxidative Stress

The development of antioxidants with high efficiency and biocompatibility is highly desired to prevent and treat free radical-related diseases. MXene, a two-dimensional (2D) ultrathin nanosheet, is a promising antioxidant material. Herein, we report a V 2 CT x MXene antioxidant that shows a significant scavenging effect on a variety of free radicals (DPPH·, ·OH, ·O 2 –, and 1 O 2 .). The scavenging efficiency for DPPH· is ∼100% in 10 min, and the EC 50 value is calculated to be 6.7 μg/mL, superior to that of most 2D and zero-dimensional materials reported so far. Furthermore, a combination of H-donation and the electron transfer mechanism was proposed based on the analysis of the free radical scavenging behavior of V 2 CT x and the reaction process. We hope that this study will provide new ideas for the treatment and prevention of ROS-mediated inflammatory and neurodegenerative diseases.