journal article·2022-05-27

Photostable Aggregation-Induced Emission Photosensitizer Nanoparticle/Hyaluronic Acid Hydrogel for Efficient Photodynamic Tooth Bleaching

Jing Gao, Junhua Wang, Xin Yue, Yuanzhu Zhou, Minghui Wang, Yiqing Sun, Qianyu Zhang, Zhiyuan Gao, Guo-Qiang Zhang, Jing Shen, Dan Ding

ACS Applied Nano Materials· Volume 5· Issue 5
Publisher page

Abstract

In this work, a highly efficient photodynamic strategy for bleaching teeth was developed, and the strategy was based on aggregation-induced emission photosensitizer nanoparticles that were embedded in a hyaluronic acid hydrogel. The bleaching effect of the photosensitizer (PS) nanoparticle hydrogel was much better than that of the 40% H2O2 hydrogel used in the clinic. Both PSs exhibited an excellent photostability and ability to produce reactive oxygen species under light irradiation, and this significantly influenced the tooth bleaching effect. Upon white light irradiation, the increase in pulp cavity temperature remained under the safety threshold of 5.5 °C, which indicates that the photodynamic bleaching strategy is very safe. Furthermore, the microstructure damage in the enamel surface and the loss of minerals in the teeth were much less severe with this method than with the 40% H2O2 hydrogel treatment.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Dental Anxiety and Anesthesia Techniques · Photodynamic Therapy Research Studies · Laser Applications in Dentistry and Medicine

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Tianjin Key Laboratory of Oral and Maxillofacial Function Reconstruction, Tianjin Stomatological Hospital, The Affiliated Stomatological Hospital of Nankai University, Tianjin 300041, China

School of Medicine, Nankai University, Tianjin 300071, China

School of Clinical Stomatology, Tianjin Medical University, Tianjin 300203, China

Frontiers Science Center for Cell Responses, State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials, Ministry of Education, and College of Life Sciences, Nankai University, Tianjin 300071, China

Funding

Tianjin Municipal Health Commission · Ministry of Science and Technology of the People's Republic of China · National Natural Science Foundation of China · Tianjin Science Fund for Distinguished Young Scholars · Tianjin Stomatological Hospital · Tianjin Key Discipline Foundation of Medicine · Tianjin Key Laboratory of Oral Function Reconstruction · Tianjin Key Medical Discipline (Specialty) Construction Project

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