journal article·2023-07-28

Ca/Fe-Based Nanozymes Relieve Severe Acute Pancreatitis by Ferroptosis Regulation and Reactive Oxygen Species Scavenging

Yuhang Li, Rui Cai, Kang Chen, Yujing Zhang, Xu Chen, Bo Sun, Yu Jiang, Chaochao Tan, Chuang Peng, Yinghui Song, Ling Wu, Sulai Liu

ACS Applied Nano Materials· Volume 6· Issue 14
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Abstract

Severe acute pancreatitis (SAP) is a serious inflammatory disease that is often associated with high mortality rate. It tends to trigger a cascade of systemic inflammation that causes damage to multiple organs, such as the lungs and kidneys. Currently, there is no effective treatment plan to reverse the progress of SAP. The occurrence and development of SAP are associated with oxidative stress (OS) and ferroptosis. In this study, the Ca/Fe-based nanozymes are used as multi-enzyme simulants, which can effectively remove the reactive oxygen species and regulate ferroptosis to prevent and treat SAP. Notably, we make two trials for prevention and treatment of SAP. Under the condition of good biocompatibility, the Ca/Fe-based nanozymes effectively reduce the levels of serum pancreatitis-related biomarkers and inflammatory factors which involved in local and systemic inflammatory response. Moreover, the Ca/Fe nanozymes significantly increase the level of ferroptosis regulator of glutathione peroxidase 4 (GPx4) and ferritin heavy chain 1 (FTH1) in pancreas. These results demonstrate that the Ca/Fe-based nanozymes not only alleviate SAP but also mitigate subsequent multi-organ damage, thus providing an effective strategy of Ca/Fe nanozymes for treating SAP-related disorders in clinical research.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Pancreatitis Pathology and Treatment · Inflammatory Biomarkers in Disease Prognosis · Pregnancy and preeclampsia studies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Hepatobiliary Surgery, The First Affiliated Hospital of Hunan Normal University, Changsha 410005, Hunan Province, China

Central Laboratory, Hunan Provincial People’s Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha 410005, Hunan Province, China

Hunan Provincial Key Laboratory of Materials Protection for Electric Power and Transportation & Hunan Provincial Key Laboratory of Cytochemistry, School of Chemistry and Biological Engineering, Changsha University of Science and Technology, Changsha 410114, Hunan Province, China

Department of Clinical Laboratory, Hunan Provincial People’s Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha 410005, Hunan Province, China

Hunan Provincial Key Laboratory of Biliary Disease Prevention and Treatment, Changsha 410005, Hunan Province, China

Clinical Medical Technology Research Center of Hunan Provincial for Biliary Disease Prevention and Treatment, Changsha 410005, Hunan Province, China

Funding

Natural Science Foundation of??Hunan Province · National Natural Science Foundation of China · Huxiang Youth Talent Support Program · Postgraduate Scientific Research Innovation Project of Hunan Province · Project of Improving the Diagnosis and Treatment Capacity of Hepatobiliary, Pancreas and Intestine in Hunan Province

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