journal article·2023-02-24

Highly Hydrophilic Oleylamine-Modified Superparamagnetic Iron Oxide Nanoparticles for Biomedical Applications

Niki Karouta, Yannis V. Simos, Georgia Basina, Konstantinos Spyrou, Mohammed Subrati, Alexandra V. Chatzikonstantinou, Mohamed Amen Hammami, Vasileios Tzitzios, Saeed M. Alhassan, Yasser Al Wahedi, Alexios P. Douvalis, George C. Hadjipanayis, Konstantinos Tsamis, Evangelia Dounousi, Georgios S. Markopoulos, Sofia Bellou, Vasilios Georgakilas, Dimitrios Peschos, Zili Sideratou, Haralambos Stamatis, Dimitrios P. Gournis, Emmanuel P. Giannelis

ACS Applied Nano Materials· Volume 6· Issue 4
Publisher page

Abstract

Superparamagnetic iron oxide nanoparticles (SPIONs) are becoming important vehicles for biomedical applications. This study demonstrates a new strategy based on a “haircut” reaction, aiming at the design of highly hydrophilic and functional nanoparticles. The as-synthesized SPIONs have a diameter of ∼4 nm and reveal super-organophilic behavior due to their surface modification by oleylamine molecules present on their surface (o-SPIONs). The “trimming”, which is applied on the oleylamine molecule double bond, produces shorter chains terminated by carboxyl groups, with the resulting nanoparticles exhibiting high hydrophilicity, dispersibility in water, and functionality (h-SPIONs). The biological behavior of h-SPIONs is studied against three different cell lines and reveals a selective cytotoxic effect against cancer cells. This novel method of engineering the surface properties of nanoparticles can lead to the development of a new generation of functional nanomaterials. In addition, h-SPIONs can evolve into a new and expanding family of magnetic nanomaterials in future biomedical systems.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Nanoparticle-Based Drug Delivery · Iron oxide chemistry and applications · Ginkgo biloba and Cashew Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Materials Science and Engineering, University of Ioannina, Ioannina 45110, Greece

Nanomedicine and Nanobiotechnology Research Group, University of Ioannina, Ioannina 45110, Greece

Laboratory of Physiology, School of Health Sciences, Department of Medicine, University of Ioannina, Ioannina 45110, Greece

Department of Chemical Engineering, Khalifa University of Science and Technology, Sas Al Nakhl Campus, P.O. Box 127788, Abu Dhabi 127788, UAE

Department of Biological Applications and Technologies, University of Ioannina, Ioannina 45110, Greece

Department of Materials Science and Engineering, Cornell University, Ithaca, New York 14853, United States

Institute of Nanoscience and Nanotechnology, NCSR “Demokritos”, Agia Parasevi-Attikis, Athens 15310, Greece

Abu Dhabi Maritime Academy, Abu Dhabi Ports, Abu Dhabi, United Arab Emirates

Department of Physics, University of Ioannina, Ioannina 45110, Greece

Department of Physics & Astronomy, University of Delaware, Newark, Delaware 19716, United States

Faculty of Medicine, University of Ioannina, Ioannina 45110, Greece

Neurosurgical Institute, University of Ioannina, Ioannina 45110, Greece

Confocal Laser scanning Microscopy Unit, Network of Research Supporting Laboratories (NRSL), University of Ioannina, Ioannina 45110, Greece

Department of Materials Science, University of Patras, Rio 26504, Patras, Greece

Funding

State Scholarships Foundation · European Regional Development Fund · Greece Government

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