journal article·2023-07-28

Carbonized Polymer Dots with Aggregation-Induced Effect for Type I Photodynamic Therapy

Li Yan, Chengshuang Liao, Yinxia Zhu, Haodong Mi, Shanshan Jiang, Feishi Shan, Yanhong Liu, Yahui Zhang, Qian Zhou, Zhouyu Wang, Xiaoqi Yu

ACS Applied Nano Materials· Volume 6· Issue 14
Publisher page

Abstract

Carbonized polymer dots (CPDs) have attracted great interest as a nanomaterial in biomedical applications, especially in imaging and photodynamic therapy (PDT). However, CPDs with an aggregation-induced effect for type I PDT has been rarely reported. In this work, N, N ′-dimethylurea and citric acid were used as precursors to prepare CPDs (YCPDs) with aggregation-induced effect in one pot by the solvothermal method. The YCPDs have a yellow emission of 550 nm and a high quantum yield of 68%, which lays a solid foundation for cell imaging. In addition, YCPDs can produce • O 2 – under white light irradiation and obtain • OH through electron transfer or hydrogen atom abstraction. In vitro results show that YCPDs possess great cytocompatibility but exert severe cytotoxicity to HeLa cells with only 2% of cell viability when exposed to ultralow-power-intensity (2.5 mW/cm 2 ) light irradiation. Therefore, YCPDs, as a promising type I PDT nanomaterial, have a great potential for cancer therapy.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Carbon and Quantum Dots Applications · Luminescence and Fluorescent Materials · Nanocluster Synthesis and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Sichuan Engineering Research Center for Molecular Targeted Diagnostic & Therapeutic Drugs, Asymmetric Synthesis and Chiral Technology Key Laboratory of Sichuan Province, Research and Application of Small Organic Chiral Molecules Key Laboratory of Yibin City, Department of Chemistry, Xihua University, Chengdu 610039, China

State Key Laboratory of Analytical Chemistry for Life Science, Key Laboratory of Mesoscopic Chemistry of MOE, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China

Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, China

Funding

National Natural Science Foundation of China · Sichuan Province Science and Technology Support Program

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