HISTOPATHOLOGICAL STUDY ON FINE CARBON FIBER POWDER INJECTED INTO THE SUBDURAL SPACE OF MICE

After the fine carbon fiber powder was injected in to the right subdural space of the mice, dynamic observation was carried out on their movement and histopathological changes. Results: 1 52 weeks after the injecting, no neurological changes concerning with the implanting of the carbon fiber powder were found in the experimental mice. The fine carbon fiber extensively located on the inter surface of the dura mater membrane of the right temporalis and the out surface of pie mater. Only slight inflammatory cells reaction was found under optical microscopes. The experimental group: one week after injecting: GradeⅡ, two week: GradeⅠ, four weeks: Grade 0, the inflammatory reaction disappeared. No obvious fiber menbrane was found around the implanted materials. No significant differences were showed between the experimental group and the contrast group. Conclusion: It was showed that the carbon fiber shares excellent histocompatibility after the fine carbon fiber powder was injected into the subdural space and subarechnoid cavity of the right temple of mice.