Preparation of carbon nanoparticle suspension with excellent lymphatic tracing properties

Carbon black(CB) was oxidized by concentrated nitric acid at 100 ℃ for 100 h to obtain a CB with excellent lymphatic tracing properties,which were characterized by XPS,alkalimetric titration and a staining test.It is found that nitric acid treatment obviously increases oxygen-containing functional groups on CB surface.The average diameter of the oxidized CB in suspension is 72 nm with no agglomeration found after storage at room temperature for 180 days.The suspension prepared with the oxidized CB can effectively color the injecting region of lymph nodes in 5 min.The staining effect is superior to a commercial available lymphatic tracer named Carbon Nanoparticle Suspension Injection.