DataVXACS Applied Nano MaterialsPaper
journal article·2022-08-26

Temperature-Sensitive Hydrogels Containing Carboxylated Chitosan-Modified Carbon Nanotubes for Controlled Drug Release

Tongyao Lin, Jinglin Zhang, Hui Long, Fengjuan Yang, Langhuan Huang, Sui-Ping Deng, Jingxian Zhang, Xiang Cai, Yunhua Yang, Shaozao Tan

ACS Applied Nano Materials· Volume 5· Issue 8
Publisher page
Source abstract

Abstract

To improve the environmental response and drug loading/release performance of hydrogels, carboxylated chitosan-modified carbon nanotubes (CCS/CNT) were synthesized as a reinforcer. Moreover, diethylacrylamide (DEA) and N-hydroxymethylacrylamide (NHMAA) acted as a temperature-sensitive monomer and a hydrophilic comonomer, respectively. Thus, a novel micro-nanomodified temperature-sensitive hydrogel (DEA-NHMAA-CNT/CCS) was fabricated via polymerization and cross-linking reactions. The results showed that DEA-NHMAA-CNT/CCS with a uniform and complete pore structure exhibited improved temperature-responsive speed, compression property, and photothermal performance. Furthermore, DEA-NHMAA-CNT/CCS owned an enhanced drug loading/release ability, displaying good temperature-controlled drug release behavior and satisfactory antibacterial activity. The advantages combining facile preparation and good overall performance suggested the great potential application of DEA-NHMAA-CNT/CCS in the fields of drug delivery, wound dressing, and tissue engineering scaffolds.
Source: openalex_inverted_index · Quality: baseline

Research context

PolymersNanomaterialsBiomaterialsComposites

OpenAlex topics: Hydrogels: synthesis, properties, applications · Advanced Sensor and Energy Harvesting Materials · Electrospun Nanofibers in Biomedical Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Guangdong Engineering & Technology Research Centre of Graphene-like Materials and Products, Department of Chemistry, College of Chemistry and Materials Science, Jinan University, Guangzhou 510632, P. R. China

School of Light Industry and Materials, Guangdong Polytechnic, Foshan 528041, P. R. China

Science and Technology Department, Guangzhou University, Guangzhou 510006, P. R. China

Guangdong Jianpai New Materials Co., Ltd., Foshan 528500, P. R. China

Funding

National Natural Science Foundation of China · Natural Science Foundation of Guangdong Province · Innovation Team Project of Foshan City · open experimental project by GETRC of Graphene-like Materials and Products · GDHVPS · Joint Project of Guangzhou City and Guangzhou University

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