Insights into the Effect of Magnetic Confinement on the Performance of Magnetic Nanocomposites in Magnetic Hyperthermia and Magnetic Resonance Imaging
Source abstract
Abstract
The combination of superparamagnetic iron oxide nanoparticles (SPIONs) and lipid matrices enables the integration of imaging, drug delivery, and therapy functionalities into smart theranostic nanocomposites. SPION confinement creates new interactions primarily among the embedded SPIONs and then between the nanocomposites and the surroundings. Understanding the parameters that rule these interactions in real interacting (nano)systems still represents a challenge, making it difficult to predict or even explain the final (magnetic) behavior of such systems. Herein, a systematic study focused on the performance of a magnetic nanocomposite as a magnetic resonance imaging (MRI) contrast agent and magnetic hyperthermia (MH) effector is presented. The effect of stabilizing agents and magnetic loading on the final physicochemical and, more importantly, functional properties (i.e., blocking temperature, specific absorption rate, relaxivity) was studied in detail.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Nanoparticle-Based Drug Delivery · Characterization and Applications of Magnetic Nanoparticles · Erythrocyte Function and Pathophysiology
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Advanced (Magnetic) Theranostic Nanostructures Lab, International Iberian Nanotechnology Laboratory, Av. Mestre José Veiga s/n, 4715-330Braga, Portugal
Department of Imaging Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, King’s College London, Strand, LondonSE1 7EH, U.K.
School of Life Sciences, Faculty of Health Sciences, University of Hull, Cottingham Road, HullHU6 7RX, U.K.
Department of Physics and Biophysics, Faculty of Food Science, University of Warmia & Mazury in Olsztyn, Oczapowskiego 4, 10-719Olsztyn, Poland
Funding
Engineering and Physical Sciences Research Council · Medical Research Council · European Regional Development Fund · Narodowe Centrum Nauki · Funda??o para a Ci?ncia e a Tecnologia
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