Effects of Lateral Size, Thickness, and Stabilizer Concentration on the Cytotoxicity of Defect-Free Graphene Nanosheets: Implications for Biological Applications
Source abstract
Abstract
In this work, we apply liquid cascade centrifugation to highly concentrated graphene dispersions produced by liquid-phase exfoliation in water with an insoluble bis-pyrene stabilizer to obtain fractions containing nanosheets with different lateral size distributions. The concentration, stability, size, thickness, and the cytotoxicity profile are studied as a function of the initial stabilizer concentration for each fraction. Our results show that there is a critical initial amount of stabilizer (0.4 mg/mL) above which the dispersions show reduced concentration, stability, and biocompatibility, no matter the lateral size of the flakes.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Graphene research and applications · Graphene and Nanomaterials Applications · Carbon and Quantum Dots Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Chemistry, University of Manchester, Oxford Road, Manchester M13 9PL, UK
Nanomedicine Lab, Faculty of Biology, Medicine and Health, AV Hill Building, University of Manchester, Manchester M13 9PL, UK
National Graphene Institute, University of Manchester, Booth Street East, Manchester M13 9PL, UK
Catalan Institute of Nanoscience and Nanotechnology (ICN2), UAB Campus Bellaterra, Barcelona 08193, Spain
Funding
Engineering and Physical Sciences Research Council · UK Research and Innovation · National Physical Laboratory · Lloyd's Register Foundation
References (46)
Show source-provided references
1. 10.1039/c2cs35387c10.1039/c2cs35387c ↗
2. 10.1021/nn400280c10.1021/nn400280c ↗
3. 10.1039/C4CS00257A10.1039/C4CS00257A ↗
4. 10.1038/nature1145810.1038/nature11458 ↗
5. 10.1038/nnano.2008.21510.1038/nnano.2008.215 ↗
6. 10.1126/science.119497510.1126/science.1194975 ↗
7. 10.1016/j.bioactmat.2020.06.01210.1016/j.bioactmat.2020.06.012 ↗
8. 10.1021/acsnano.9b0363210.1021/acsnano.9b03632 ↗
9. 10.1039/C3CS60217F10.1039/C3CS60217F ↗
10. 10.1021/jp400800910.1021/jp4008009 ↗
11. 10.1039/C6RA10933K10.1039/C6RA10933K ↗
12. 10.1039/D1MH01117K10.1039/D1MH01117K ↗
13. 10.1016/j.carbon.2021.09.07510.1016/j.carbon.2021.09.075 ↗
14. 10.1039/C9FD00114J10.1039/C9FD00114J ↗
15. 10.1039/D0NR02689A10.1039/D0NR02689A ↗
16. 10.1021/nn302784m10.1021/nn302784m ↗
17. 10.1039/C9ME00024K10.1039/C9ME00024K ↗
18. 10.1039/c3nr00258f10.1039/c3nr00258f ↗
19. 10.1016/j.carbon.2012.11.02210.1016/j.carbon.2012.11.022 ↗
20. 10.1039/D0NR05514J10.1039/D0NR05514J ↗
21. 10.1039/C6TB02344D10.1039/C6TB02344D ↗
22. 10.1021/acsnano.5b0722810.1021/acsnano.5b07228 ↗
23. 10.1021/ed039p33310.1021/ed039p333 ↗
24. Hunter R. J. · 1982
25. Pecora R. · 198510.1007/978-1-4613-2389-1 ↗
26. 10.1021/acsnano.7b0773710.1021/acsnano.7b07737 ↗
27. 10.1002/cphc.20150111310.1002/cphc.201501113 ↗
28. 10.1038/srep1668410.1038/srep16684 ↗
29. 10.1002/smll.20140274510.1002/smll.201402745 ↗
30. 10.1002/anie.20140269610.1002/anie.201402696 ↗
31. 10.1016/j.carbon.2016.02.03710.1016/j.carbon.2016.02.037 ↗
32. 10.1088/1367-2630/12/12/12500810.1088/1367-2630/12/12/125008 ↗
33. 10.1021/acsnano.9b0223410.1021/acsnano.9b02234 ↗
34. 10.1021/acs.chemmater.6b0333510.1021/acs.chemmater.6b03335 ↗
35. 10.1021/la903188a10.1021/la903188a ↗
36. 10.1021/nl803269710.1021/nl8032697 ↗
37. 10.1039/C1CS15188F10.1039/C1CS15188F ↗
38. 10.1002/adma.20120370010.1002/adma.201203700 ↗
39. 10.1021/acsnano.8b0475810.1021/acsnano.8b04758 ↗
40. 10.1021/acsnano.7b0773410.1021/acsnano.7b07734 ↗
41. 10.1021/ar300199e10.1021/ar300199e ↗
42. 10.1021/nn700256c10.1021/nn700256c ↗
43. 10.1021/bm900683r10.1021/bm900683r ↗
44. 10.1016/j.tiv.2013.12.01210.1016/j.tiv.2013.12.012 ↗
45. 10.1007/s11434-013-6058-x10.1007/s11434-013-6058-x ↗
46. 10.1021/acs.chemrestox.1c0024310.1021/acs.chemrestox.1c00243 ↗