journal article·2020-10-23

Urchin-like Porous Silica Nanoparticles for Simultaneous Intracellular Delivery of Doxorubicin and RNase A

Hang Zhang, Jiaxi Ru, Xiaoliang Tang, Huichen Guo

ACS Applied Nano Materials· Volume 3· Issue 10
Publisher page

Abstract

Urchin-like porous silica nanoparticles (UPSNs) with hierarchical dual-pore structure and tunable particle size have been synthesized by utilizing sodium salicylate (NaSal) and cetyltrimethylammonium bromide (CTAB) as co-structure-directing agents in aqueous solution. The effects of various experimental parameters on these tunable UPSNs have been systematically investigated. Interestingly, the particle size and pore structure transition from a uniform small mesopore to a hierarchical dual pore can be effectively changed by simply adjusting the concentrations of NaSal. Furthermore, a possible mechanism for the formation of the UPSNs with a hierarchical dual-pore structure was proposed based on the synthesized parameter and influence factor. Finally, the typical UPSNs were further used as an efficient codelivery nanocarrier for intracellular delivery of DOX and RNase A. Our results demonstrated that the UPSNs with a hierarchical dual-pore structure are promising drug codelivery nanocarriers.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Mesoporous Materials and Catalysis · Layered Double Hydroxides Synthesis and Applications · Anodic Oxide Films and Nanostructures

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province and State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, P. R. China

State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu Province 730046, P. R. China

Funding

State Administration of Foreign Experts Affairs · Central Public-interest Scientific Institution Basal Research Fund for Chinese Academy of Tropical Agricultural Sciences · Ministry of Education of the People's Republic of China · Ministry of Science and Technology of the People's Republic of China · National Natural Science Foundation of China · Gansu Province

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