DataVXACS Applied Nano MaterialsPaper
journal article·2024-04-26

Cu-MOF/Aptamer/Magnetic Bead Sensor for Detection of Breast Cancer Biomarkers HER2 and ER

Xiaofang Liu, Ya Zhang, Ning Li, Zhihao Yang, Siyi Yang, Jiawei Li, Jian Chen, Danqun Huo, Changjun Hou

ACS Applied Nano Materials· Volume 7· Issue 8
Publisher page
Source abstract

Abstract

Cancer markers are used for early cancer detection and follow-up monitoring so that patients receive the most appropriate treatment to alleviate suffering and prolong life. Herein, a metal–organic framework (MOF) combined with magnetic beads (MB) is proposed as a nanosensor for detecting breast cancer biomarkers based on magnetic enrichment and separation. With the porous structure of Cu-MOF, a large number of aptamers are adsorbed inside the pore to specifically capture the antigen. Then, Cu-MOF@antigen is enriched and separated by MB modified with the corresponding antibody. Supernatant Cu-MOF and Cu-MOF@antigen@MB are used as colorimetric, fluorescent, and electrochemical sensing elements for the quantitative detection of HER2 and ER. The detection ranges for HER2 and ER are 4.5 fg/mL–20 ng/mL and 10 fg/mL–20 ng/mL, respectively. It also demonstrated good performance in the detection of human serum samples, with recoveries ranging from 89.00 to 107.57%. This nanosensor has promising selectivity, stability, and practical applicability, providing the possibility for its in-depth development.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Advanced biosensing and bioanalysis techniques · Advanced Nanomaterials in Catalysis · Dendrimers and Hyperbranched Polymers

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Key Laboratory for Biorheological Science and Technology of Ministry of Education, Bioengineering College of Chongqing University, Chongqing 400044, PR China

Chongqing University Three Gorges Hospital, Chongqing 404000, PR China

Postdoctoral Research Station, School of Microelectronics and Communication Engineering, Chongqing University, Chongqing 400044, PR China

Chongqing Key Laboratory of Bio-perception & Intelligent Information Processing, School of Microelectronics and Communication Engineering, Chongqing University, Chongqing 400044, PR China

Funding

Graduate School, Chongqing University · Science and Technology Department of Sichuan Province · National Research Center for Translational Medicine Shanghai · Special project for performance incentive and guidance of Chongqing scientific research institutions · Brew Microorganisms Technology and Application of Key Laboratory Project in Sichuan Province · Chongqing Graduate Tutor Team Construction Project

References (36)

Show source-provided references
1. 10.1016/S1470-2045(18)30162-110.1016/S1470-2045(18)30162-1 ↗
2. 10.1016/j.cell.2023.01.04010.1016/j.cell.2023.01.040 ↗
3. 10.3322/caac.2166010.3322/caac.21660 ↗
4. 10.1016/j.bios.2022.11450810.1016/j.bios.2022.114508 ↗
5. 10.1136/bmj.p29010.1136/bmj.p290 ↗
6. 10.1021/acs.analchem.3c0060810.1021/acs.analchem.3c00608 ↗
7. 10.1021/acs.analchem.3c0195710.1021/acs.analchem.3c01957 ↗
8. 10.1016/j.bios.2019.11198410.1016/j.bios.2019.111984 ↗
9. 10.1515/cclm-2022-109010.1515/cclm-2022-1090 ↗
10. 10.1016/j.ctrv.2021.10228610.1016/j.ctrv.2021.102286 ↗
11. 10.1200/JCO.2012.44.695510.1200/JCO.2012.44.6955 ↗
12. 10.1039/C8NR08337A10.1039/C8NR08337A ↗
13. 10.1016/S1470-2045(21)00301-610.1016/S1470-2045(21)00301-6 ↗
14. 10.1016/j.clbc.2019.07.01310.1016/j.clbc.2019.07.013 ↗
15. 10.1023/a:100959472735810.1023/a:1009594727358 ↗
16. 10.1016/j.bios.2017.07.04310.1016/j.bios.2017.07.043 ↗
17. 10.1378/chest.12-012310.1378/chest.12-0123 ↗
18. 10.5306/wjco.v5.i3.38210.5306/wjco.v5.i3.382 ↗
19. 10.1016/j.ab.2022.11482010.1016/j.ab.2022.114820 ↗
20. 10.1016/j.aca.2020.08.03010.1016/j.aca.2020.08.030 ↗
21. 10.1016/j.trac.2022.11660510.1016/j.trac.2022.116605 ↗
22. 10.1016/j.trac.2022.11680610.1016/j.trac.2022.116806 ↗
23. 10.1126/sciadv.abj085210.1126/sciadv.abj0852 ↗
24. 10.1002/advs.20200147610.1002/advs.202001476 ↗
25. 10.1002/adma.20180020210.1002/adma.201800202 ↗
26. 10.1016/j.cej.2022.13993110.1016/j.cej.2022.139931 ↗
27. 10.1016/j.tifs.2021.04.00410.1016/j.tifs.2021.04.004 ↗
28. 10.1016/j.trac.2022.11673510.1016/j.trac.2022.116735 ↗
29. 10.1002/adfm.20221227710.1002/adfm.202212277 ↗
30. 10.1002/cmdc.20190069710.1002/cmdc.201900697 ↗
31. 10.1016/j.bios.2022.11457510.1016/j.bios.2022.114575 ↗
32. 10.7150/thno.1792710.7150/thno.17927 ↗
33. 10.1021/acs.analchem.2c0304610.1021/acs.analchem.2c03046 ↗
34. 10.1016/j.bios.2021.11330510.1016/j.bios.2021.113305 ↗
35. 10.1021/acsami.7b0730710.1021/acsami.7b07307 ↗
36. 10.1021/ja00400a07510.1021/ja00400a075 ↗