CoSe₂ Nanoparticles with Multienzymic Activities for Antibacterial Applications

Increasing bacterial resistance has led to the aggravation of diseases caused by microbial infections, posing a significant threat to human health. The multicascade approach is more efficient than a single treatment for resistant bacteria. Here, we describe the simple method of fabricating CoSe 2 nanoparticles, which operate as a single-component, multienzyme-mimicking nanoplatform for multiple ROS production. The nanoplatform simultaneously exhibits multienzymatic activities that mimic intrinsic catalase, peroxidase, and oxidase. Furthermore, under the synergistic action of 808 nm NIR, the multienzyme cascade action and ROS produced by photodynamics play a stronger role against drug-resistant extended-spectrum β-lactamase-producing Escherichia coli . Therefore, this study reveals the potential of CoSe 2 nanoparticles as efficient antimicrobial reagents, providing a promising alternative nanozyme for biomedical use.