journal article·2019-06-28

Experimental and Theoretical Structural Characterization of Cu–Au Tripods for Photothermal Anticancer Therapy

Sitansu Sekhar Nanda, K. P. S. S. Hembram, Jae-Kap Lee, Kwangmeyung Kim, Subramanian Tamil Selvan, Dong Kee Yi

ACS Applied Nano Materials· Volume 2· Issue 6
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Abstract

Anisotropic metal nanostructures (e.g., Au–Ag, Au–Cu) are emerging for biomedical and catalytic applications in recent years. Herein, we report a modified synthesis of Cu–Au tripod nanocrystals through the controlled nucleation and growth process with judicious purification for photothermal based anticancer therapy. The distribution of nanocrystals in tripod was analyzed by STEM-EDX mapping, indicating the formation of Cu–Au alloy nanocrystals. Theoretical calculations showed the possible formation of alloy structures, that is, Cu3Au, Cu–Au, and CuAu3 and confirmed that their stability in the following order: CuAu3 < Cu–Au < Cu3Au. These stable tripods exhibited a well pronounced photothermal effect as demonstrated by experimental and simulation photothermal studies. Cancer cells treated with nanocrystals upon NIR laser exposure showed promising therapeutic effects.
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Research context

OpenAlex topics: Gold and Silver Nanoparticles Synthesis and Applications · Laser-Ablation Synthesis of Nanoparticles · Nanocluster Synthesis and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemistry, Myongji University, Yongin, 03674, South Korea

Optoelectronic Materials and Devices Research Center, Korea Institute of Science and Technology (KIST), Seoul, 02792, South Korea

Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul, 02792, South Korea

KU-KIST Graduate School of Converging Science and Technology, Seoul, 02841, South Korea

Lee Kong Chian School of Medicine, Nanyang Technological University, 59 Nanyang Drive, 636921 Singapore

Department of Environmental Engineering, Myongji University, Yongin, 03674, South Korea

Funding

NRF, Korea

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