DataVXACS Applied Nano MaterialsPaper
journal article·2022-01-28

Peptide Hydrogels Assembled from Enzyme-Adsorbed Mesoporous Silica Nanostructures for Thermoresponsive Doxorubicin Release

Bing Li, Miryam Criado-Gonzalez, Alexandre Adam, Joëlle Bizeau, Christophe Mélart, Alain Carvalho, Sylvie Bégin, Dominique Bégin, Loïc Jierry, Damien Mertz

ACS Applied Nano Materials· Volume 5· Issue 1
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Source abstract

Abstract

The development of nanocomposite supramolecular hydrogels, which can be activated by local or external stimuli (pH, redox, enzyme, heat), is highly promising for various applications including implantable materials for antitumor or tissue engineering applications. Here, we show that large pore stellate mesoporous silica modified with isobutyramide grafts allow >100% wt. loading of enzymes, which ensures through the enzyme-assisted self-assembly an easy, rapid, and efficient way to design smart thermoresponsive nanocomposite supramolecular hydrogels. The typical temperature increase (42 °C), which may be induced by hyperthermia anticancer treatments, leads to the controlled-release of doxorubicin encapsulated in the resulting peptide self-assembled material.
Source: openalex_inverted_index · Quality: baseline

Research context

PolymersNanomaterialsBiomaterials

OpenAlex topics: Supramolecular Self-Assembly in Materials · Polydiacetylene-based materials and applications · Supramolecular Chemistry and Complexes

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Institut de Physique et Chimie des Matériaux de Strasbourg (IPCMS), UMR-7504 CNRS-Université de Strasbourg, 23 rue du Lœss, BP 34, 67034 Cedex 2 Strasbourg, France

Institut de Chimie et Procédés pour l’Energie, l’Environnement et la Santé (ICPEES), UMR-7515 CNRS-Université de Strasbourg, 25 rue Becquerel, 67087 Cedex 2 Strasbourg, France

Université de Strasbourg, CNRS, Institut Charles Sadron (UPR22), 23 rue du Loess, BP 84047, 67034 Cedex 2 Strasbourg, France

Funding

Agence Nationale de la Recherche · Materials Institute Carnot Alsace · Chinese Scholarship Council

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