DataVXACS Applied Nano MaterialsPaper
journal article·2018-04-27

In Situ Synthesis of CuS Nanoparticle-Doped Poly(N-isopropylacrylamide)-Based Microgels for Near-Infrared Triggered Photothermal Therapy

Tong Shu, Qiming Shen, Lei Su, Xueji Zhang, Michael J. Serpe

ACS Applied Nano Materials· Volume 1· Issue 4
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Source abstract

Abstract

Poly(N-isopropylacrylamide)-co-(acrylic acid) (pNIPAm-co-AAc) microgels incorporated with CuS nanoparticles (CuSNPs) were synthesized and employed for near-infrared (NIR) triggered photothermal killing of cancer cells. Cu2+ was enriched in the microgels through deprotonation of the pNIPAm-co-AAc microgels at high solution pH. CuSNPs were subsequently generated within the pNIPAm-co-AAc microgels upon exposure to heat and S2–. The solution of hybrid microgels showed an absorption peak in the NIR region (∼1000 nm). After demonstrating that the hybrid microgels were not cytotoxic, we showed that NIR excitation of the hybrid microgels could be used to kill HeLa cells. Almost 90% of the HeLa cells were killed when incubated with 400 μg/mL of the hybrid microgels and exposed to 808 nm laser light with a power density of 2 W/cm2 for 10 min. While these materials show promise for photothermal therapy, they can also be incorporated into a hydrogel matrix that can be triggered to release small molecule drugs upon exposure to NIR wavelengths.
Source: openalex_inverted_index · Quality: baseline

Research context

PolymersNanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Nanoparticle-Based Drug Delivery · Gold and Silver Nanoparticles Synthesis and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Beijing Key Laboratory for Bioengineering and Sensing Technology, Research Center for Bioengineering and Sensing Technology, School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083, P. R. China

Department of Chemistry, University of Alberta, Edmonton, Alberta T6G 2G2, Canada

Funding

Ministry of Education of the People's Republic of China · Canada Foundation for Innovation · Natural Science Foundation of Beijing Municipality · Grand Challenges Canada · Natural Sciences and Engineering Research Council of Canada · National Natural Science Foundation of China · Faculty of Science, University of Alberta · India-Canada Centre for Innovative Multidisciplinary Partnerships to Accelerate Community Transformation and Sustainability · Beijing Municipal Science and Technology Commission · Department of Chemistry, University of Alberta

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