DataVXACS Applied Nano MaterialsPaper
journal article·2022-04-22

Glioblastoma Homing Photodynamic Therapy Based on Multifunctionalized Porous Silicon Nanoparticles

Rae Hyung Kang, Youngwoong Kim, Hye Ji Um, Jaehoon Kim, Eun-Kyoung Bang, Seung Geun Yeo, Dokyoung Kim

ACS Applied Nano Materials· Volume 5· Issue 4
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Source abstract

Abstract

Photodynamic therapy (PDT) is a clinically approved minimally invasive therapy for malignant diseases. Indocyanine green (ICG) is a prominent photosensitive agent for PDT, but it has intrinsic drawbacks such as aggregation, instability, and photolytic degradation. Although numerous nanoparticle-based approaches have been studied to overcome such issues, there are still limitations such as potential immunogenicity and unprecise and inefficient delivery to the tumor. In this study, we disclosed a nanoformulation (SIWV-pSiNP(ICG)), SIWV peptide-functionalized glioblastoma (GBM) homing, and ICG-incorporated porous silicon nanoparticles (pSiNPs). The nanoformulation demonstrated an enhanced photodynamic property under NIR light irradiation with improved stability of the incorporated ICG. The SIWV-pSiNP(ICG) also showed significant targeting ability to the GBM cells with nontoxicity and laser-triggered ROS generation in situ. As a result, the SIWV-pSiNP(ICG) showed superior therapeutic efficacy (anticancer efficiency) with excellent biocompatibility in the GBM xenograft mice. This work presents a novel and efficient strategy to enhance PDT efficacy for the targeted GBM therapy.
Source: openalex_inverted_index · Quality: baseline

Research context

NanomaterialsBiomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Photodynamic Therapy Research Studies · Nanowire Synthesis and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea

Medical Research Center for Bioreaction to Reactive Oxygen Species and Biomedical Science Institute, Kyung Hee University, Seoul 02447, Republic of Korea

Creative Research Center for Brain Science, Brain Science Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea

KHU-KIST Department of Converging Science and Technology, Kyung Hee University, Seoul 02447, Republic of Korea

Department of Otorhinolaryngology, Head & Neck Surgery, Kyung Hee University, Seoul 02447, Republic of Korea

Department of Anatomy and Neurobiology, College of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea

Center for Converging Humanities, Kyung Hee University, Seoul 02447, Republic of Korea

Funding

Korea Health Industry Development Institute · National Research Foundation of Korea · Korea Institute of Science and Technology

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