Zeolite-Like Ln-MOF Luminescent Nanosensor for Highly Efficient Detection of l-Noradrenaline

l -Noradrenaline ( l -NE) is a neurotransmitter released by postganglionic neurons in the sympathetic nerve branch and stimulates the secretion of l -NE in human blood. Accurate monitoring of the l -NE concentration in serum is crucial for detecting stimulants and preventing fraud in competitive events. In this study, we introduce an approach for the detection of l -NE using a zeolite-like lanthanide metal–organic framework (Ln-MOF) named Eu 0.479 Tb 0.521 -ZMOF, constructed with a H 2 bpdc ligand (where H 2 bpdc stands for 2,2′-bipyridine-6,6′-dicarboxylate acid), and forming a nanorod. Notably, the ratiometric luminescent probe Eu 0.479 Tb 0.521 -ZMOF showcases superior sensing performance compared to single emission based on Ln-MOF, enabling highly efficient detection of l -NE among various antidepressant hormones. The limit of detection (LOD) for l -NE was 129 μM. Additionally, Eu 0.479 Tb 0.521 -ZMOF has been synthesized into nanorods, which promote effective detection of l -NE in human serum solutions, exhibiting an impressive recovery rate ranging from 97.5 to 100%. Additionally, a luminescent membrane, derived from Eu 0.479 Tb 0.521 -ZMOF, was successfully developed and utilized for visual detection of l -NE. In conclusion, our study comprehensively elucidates the detailed detection mechanism for l -NE based on zeolite-Like Ln-MOFs Eu 0.479 Tb 0.521 -ZMOF.