DataVXACS Applied Nano MaterialsPaper
journal article·2023-04-28

Antimicrobial Peptide Nanoparticle-Based Microneedle Patches for the Treatment of Bacteria-Infected Wounds

Biao Wang, Donghui Zhao, Yuting Li, Xinpei Zhou, Zexuan Hui, Xiaoling Lei, Lin Qiu, Yang Bai, Cheng Wang, Jiang Xia, Yang Xuan, Pengju Jiang, Jianhao Wang

ACS Applied Nano Materials· Volume 6· Issue 8
Publisher page
Source abstract

Abstract

To avoid the production of drug resistance during the antibiotic treatment of wound infection, the use of antimicrobial peptides (AMPs) has been strongly developed. However, its application is limited by low bioavailability, rapid degradation of AMP, and the difficulty of deep-tissue bacterial elimination. To solve this problem, AMP and recombinant type III humanized collagen (Col III)-contained microneedle patches were designed to achieve slow and controlled release of AMP and Col III to effectively eliminate the bacteria in the deep wound tissue and promote wound healing. AMP (KKLRLKIAFK) coupled with Cy3 was encapsulated in the nanogel (CGA-NPs), which was formed by chitosan (CS) and gum arabic (GA) through electrostatic interactions. Microneedle (MN) patches were dissolved after penetrating the infected skin and biofilm formed by Staphylococcus aureus to release CGA-NPs. AMPs was released responding to the infected microenvironment to efficiently kill bacteria, and Col III was beneficial to promote wound healing. This is a strategy for the design and application of a microneedle-based antimicrobial drug delivery system.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Antimicrobial Peptides and Activities · Advancements in Transdermal Drug Delivery · Bacterial biofilms and quorum sensing

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Pharmacy, Changzhou University, Changzhou, Jiangsu 213164, China

Britton Chance Center for Biomedical Photonics at Wuhan National Laboratory for Optoelectronics-Hubei Bioinformatics and Molecular Imaging Key Laboratory, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China

Department of Chemistry, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China

Key Lab of Biotechnology and Bioresources Utilization of Ministry of Education, College of Life Science, Dalian Minzu University, Dalian, Liaoning 116600, China

Funding

Research Grants Council, University Grants Committee · Changzhou Science and Technology Bureau · Dalian Minzu University · National Natural Science Foundation of China · Postgraduate Research and Practice Innovation Program of Jiangsu Province · CUHK-University of Manchester · Natural Science Foundation of Jiangsu Province

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