journal article·2022-03-25

Redox-Responsive Functional Iron Oxide Nanocrystals for Magnetic Resonance Imaging-Guided Tumor Hyperthermia Therapy and Heat-Mediated Immune Activation

Yao Li, Xiaotu Ma, Xiaoli Liu, Yale Yue, Keman Cheng, Qiang Zhang, Guangjun Nie, Xiao Zhao, Lei Ren

ACS Applied Nano Materials· Volume 5· Issue 3
Publisher page

Abstract

Magnetic nanoparticle-mediated mild hyperthermia is an emerging approach for tumor treatment and antitumor immune activation. However, the precise delivery of magnetic hyperthermia nanoagents inside tumor for mild magnetic hyperthermia therapy (MHT) via intravenous administration remains challenging. In this study, we developed a tumor microenvironment (TME)-responsive nanosystem based on cleavable methoxypolyethene glycol (mPEG) and transactivator of transcription (TAT) cell-penetrating peptide dual-decorated Fe3O4 nanocrystals (mPEG@TAT@Fe3O4) and utilized it to facilitate effective magnetic resonance (MR) imaging, tumor MHT, and mild heat-mediated immune stimulation. The as-constructed mPEG@TAT@Fe3O4 exhibited supreme sensitivity to the reducing environment in the TME for detaching the mPEG shell and strongly inhibited the proliferation of tumor cells with exposure to an alternating magnetic field. In vivo experiments in CT26 tumor-bearing mice showed that this nanodelivery system received an enhanced T2-weighted MR imaging-guided tumor MHT by achieving an 85.5% tumor inhibition rate and induced a magnetic hyperthermia–immune synergistic therapy. Notably, the structure–variable delivery system showed a lower intravenous dosage than previously reported agents at a temperature of 43–44 °C induced by MHT. Together with no obvious agent-related adverse events, our study successfully prepared a promising systemic delivery nanomedicine for MR imaging-guided tumor-targeting MHT and provided an attractive method to turn “cold” tumor to “hot”.
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Research context

OpenAlex topics: Nanoparticle-Based Drug Delivery · Nanoplatforms for cancer theranostics · Extracellular vesicles in disease

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

The Higher Educational Key Laboratory of Biomedical Engineering of Fujian Province, Research Center of Biomedical Engineering of Xiamen, Department of Biomaterials, College of Materials, Xiamen University, Xiamen, Fujian 361005, China

CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, No. 11 Zhongguancun Beiyitiao, Beijing 100190, China

Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education; Provincial Key Laboratory of Biotechnology of Shaanxi Province, Northwest University, Xi’an, Shaanxi 710069, China

Institute of Regenerative and Reconstructive Medicine, Med-X Institute, National Local Joint Engineering Research Center for Precision Surgery & Regenerative Medicine, Shaanxi Provincial Center for Regenerative Medicine and Surgical Engineering, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi 710061, China

IGDB-NCNST Joint Research Center, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China

State Key Laboratory of Physical Chemistry of Solid Surface, School of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, P.R. China

Funding

Natural Science Foundation of Beijing Municipality · National Natural Science Foundation of China · Beijing Nova Program · Chinese Academy of Sciences · Xiamen University

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