journal article·2021-01-22Open access

Lanthanide–Cyclen–Camptothecin Nanocomposites for Cancer Theranostics Guided by Near-Infrared and Magnetic Resonance Imaging

Yonghong Zhang, Xia Ma, Ho-Fai Chau, Waygen Thor, Lijun Jiang, Shuai Zha, Wan-Yiu Fok, Ho-Nam Mak, Junhui Zhang, Jing Cai, Chi-Fai Ng, Hongguang Li, David Parker, Li Li, Ga-Lai Law, Ka-Leung Wong

ACS Applied Nano Materials· Volume 4· Issue 1

Abstract

We have devised a molecular-to-micellar strategy to incorporate a lanthanide nanoplatform for the delivery of an anticancer drug that simultaneously offers hybrid near-infrared (NIR) and magnetic resonance imaging (MRI) capabilities with defined lanthanide(III) ratio control. This cancer-selective lanthanide-based self-assembled nanocomposite (LnNPs) has been synthesized by conjugating lanthanide–cyclen complexes (cycLn) with a well-known drug–camptothecin (CPT) through a redox-sensitive disulfide bond (−ss–). By accurately controlling the ratio of Gd(III) and Yb(III) complexes, we prepared hybrid nanoparticles (Gd/YbNPs) with both NIR and MR imaging properties. The enhanced stability at ultralow critical aggregation concentrations (CACs), simultaneous optical and MR imaging, improved delivery/chemotherapeutic efficiency, and cancer cell selectivity of such nanomicellar theranostic prodrugs in vitro and in vivo have thus been achieved and validated. The work provides a blueprint combining a stimuli-activated NIR luminescence and real-time MR imaging into a safe and biocompatible nanoplatform for selective cancer treatment.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Nanoparticle-Based Drug Delivery · Lanthanide and Transition Metal Complexes

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Kowloon, Hong Kong SAR, China

Key Laboratory of Energy Materials Chemistry, Ministry of Education; Key Laboratory of Advanced Functional Materials, Autonomous Region; Urumqi Key Laboratory of Green Catalysis and Synthesis Technology, College of Chemistry, Xinjiang University, Urumqi 830046, Xinjiang, China

Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong SAR, China

State Key Laboratory of Oncology in South China, Imaging Diagnosis and Interventional Center, Sun Yat-sen University Cancer Center, Guangzhou 510060, China

Department of Surgery, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China

School of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, China

Department of Chemistry, Durham University, South Road, Durham DH1 3LE, United Kingdom

Funding

Research Grants Council, University Grants Committee · CAS-Croucher Funding Scheme for Joint Laboratories · Hong Kong Baptist University · China Postdoctoral Science Foundation · National Natural Science Foundation of China · Hong Kong Polytechnic University · Research Foundation of Department of Education of Guangdong Province

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