journal article·2020-02-28

Poly(2-Hydroxyethyl Methacrylate) Sponges Doped with Ag Nanoparticles as Antibacterial Agents

Praveen, Shuko Suzuki, Christine F. Carson, Martin Saunders, Peta L. Clode, Matthew Myers, Traian V. Chirila, Murray V. Baker

ACS Applied Nano Materials· Volume 3· Issue 2
Publisher page

Abstract

Poly(2-hydroxyethyl methacrylate) sponges doped with silver nanoparticles (Ag NP-PHEMA) were prepared by irradiation of aqueous solutions containing 2-hydroxyethyl methacrylate (HEMA) and silver nitrate in the presence of a cross-linking agent and a photoinitiator. The Ag NP-PHEMA sponges had polymer droplet morphology with interconnected pores, characteristic of PHEMA sponges prepared by polymerization-induced phase separation. The Ag NP-PHEMA sponges were yellow-brown, whereas PHEMA sponges were white. For formation of Ag NP-PHEMA, the size of the polymer droplets was larger and the rate of polymerization was increased compared to PHEMA sponges formed under similar conditions but in the absence of silver nitrate. Mechanical strength, as indicated by compression testing, was similar for Ag NP-PHEMA and PHEMA sponges. Nanoparticles slowly leached out of Ag NP-PHEMA sponges, exerting antibacterial activity against Escherichia coli (Gram-negative) and Staphylococcus aureus (Gram-positive) bacteria. Notably, Ag NPs that leached were nontoxic to human corneal epithelial (HCE-T) cells.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Nanoparticles: synthesis and applications · Nanoplatforms for cancer theranostics · Advanced Photocatalysis Techniques

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

UWA School of Molecular Sciences, The University of Western Australia, Crawley, Western Australia 6009, Australia

Queensland Eye Institute, 140 Melbourne Street, South Brisbane, Queensland 4101, Australia

UWA School of Biomedical Sciences, The University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia

Centre for Microscopy, Characterisation, and Analysis, The University of Western Australia, Crawley, Western Australia 6009, Australia

UWA School of Biological Sciences, The University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia

Commonwealth Scientific and Industrial Research Organisation, Energy, 26 Dick Perry Avenue, Kensington, Western Australia 6155, Australia

Faculty of Science and Engineering, Queensland University of Technology, Brisbane, Queensland 4001, Australia

Australian Institute of Bioengineering & Nanotechnology, The University of Queensland, St. Lucia, Queensland 4072, Australia

Faculty of Medicine, The University of Queensland, Herston, Queensland 4029, Australia

Funding

University of Western Australia · Australian Research Council

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