DataVXACS Applied Nano MaterialsPaper
journal article·2021-06-25

BOPHY-Based Aggregation-Induced-Emission Nanoparticle Photosensitizers for Photodynamic Therapy

Fangyuan Lv, Dapeng Liu, Wen-heng Zheng, Yanliang Zhao, Fengling Song

ACS Applied Nano Materials· Volume 4· Issue 6
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Source abstract

Abstract

Photosensitizers for photodynamic therapy (PDT) of cancer have been widely investigated over the past decades. However, the notorious aggregation-caused quenching (ACQ) effect limits their further biological applications. In this work, we have designed and reported a photosensitizer BOPHY-2TPA. The formed photosensitizer BOPHY-2TPA was a donor–acceptor–donor (D–A–D) structure with the BOPHY as an acceptor core and two triphenylamine (TPAs) as the electron donor units. The BOPHY-2TPA exhibited a large Stokes shift and excellent photoinduced 1O2 generation capabilities. Besides, the twisted structure of TPAs endowed the BOPHY-2TPA with intrinsic AIE properties, which effectively avoided the ACQ effect. Because of these prominent features, the BOPHY-2TPA aggregates encapsulated with biocompatible Pluronic P123 in aqueous solution showed high PDT antitumor efficiency.
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Research context

NanomaterialsBiomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Luminescence and Fluorescent Materials · Photodynamic Therapy Research Studies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Institute of Molecular Science and Engineering, Institute of Frontier and Interdisciplinary Science, Shandong University, Qingdao, Shandong 266237, China

Department of Medical Imaging, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang 110042, China

State Key Laboratory of Fine Chemicals, Dalian University of Technology, 2 Linggong Road, Dalian 116024, China

Funding

Ministry of Education of the People's Republic of China · National Natural Science Foundation of China · Key R&D Program of Shandong Province · Fundamental Research Funds of Shandong University · Guangdong basic and applied basic research foundation

References (46)

Show source-provided references
1. 10.1016/j.biopha.2018.07.04910.1016/j.biopha.2018.07.049 ↗
2. 10.1039/C6CS00616G10.1039/C6CS00616G ↗
3. 10.1007/s10863-006-9064-810.1007/s10863-006-9064-8 ↗
4. 10.1016/S0169-409X(01)00126-010.1016/S0169-409X(01)00126-0 ↗
5. 10.1002/anie.20200383610.1002/anie.202003836 ↗
6. 10.1039/C5CS00364D10.1039/C5CS00364D ↗
7. 10.1016/j.ccr.2018.03.00210.1016/j.ccr.2018.03.002 ↗
8. 10.1021/acsami.0c1275610.1021/acsami.0c12756 ↗
9. 10.1021/acs.analchem.8b0502410.1021/acs.analchem.8b05024 ↗
10. 10.1039/C2CS35216H10.1039/C2CS35216H ↗
11. 10.1039/c2ra21404k10.1039/c2ra21404k ↗
12. 10.1021/ja107193j10.1021/ja107193j ↗
13. 10.1039/c2sc20537h10.1039/c2sc20537h ↗
14. 10.1021/ja047649e10.1021/ja047649e ↗
15. 10.1021/ja052853310.1021/ja0528533 ↗
16. 10.1002/anie.20200284310.1002/anie.202002843 ↗
17. 10.1021/jacs.8b0492910.1021/jacs.8b04929 ↗
18. 10.1016/j.aca.2018.10.03810.1016/j.aca.2018.10.038 ↗
19. 10.1021/jacs.7b0591610.1021/jacs.7b05916 ↗
20. 10.1016/j.actbio.2020.05.01310.1016/j.actbio.2020.05.013 ↗
21. 10.1016/j.addr.2019.05.00910.1016/j.addr.2019.05.009 ↗
22. 10.1021/acsnano.7b0031210.1021/acsnano.7b00312 ↗
23. 10.1021/ja502477a10.1021/ja502477a ↗
24. 10.1021/ol501162f10.1021/ol501162f ↗
25. 10.1002/adma.20180135010.1002/adma.201801350 ↗
26. 10.1021/acs.nanolett.0c0277810.1021/acs.nanolett.0c02778 ↗
27. 10.1002/adma.20170107610.1002/adma.201701076 ↗
28. 10.1117/1.JPE.8.03210310.1117/1.JPE.8.032103 ↗
29. 10.1021/jacs.8b1388910.1021/jacs.8b13889 ↗
30. 10.1039/C8OB00272J10.1039/C8OB00272J ↗
31. 10.1021/jacs.9b0932310.1021/jacs.9b09323 ↗
32. 10.1039/B204251G10.1039/B204251G ↗
33. 10.1002/ejoc.20110032410.1002/ejoc.201100324 ↗
34. 10.1021/acs.macromol.6b0095810.1021/acs.macromol.6b00958 ↗
35. 10.1021/acs.joc.7b0241510.1021/acs.joc.7b02415 ↗
36. 10.1039/C5TC03933A10.1039/C5TC03933A ↗
37. 10.1021/cr940745l10.1021/cr940745l ↗
38. 10.1021/ja040095v10.1021/ja040095v ↗
39. 10.1021/acsnano.9b0797210.1021/acsnano.9b07972 ↗
40. 10.1002/adma.20180210510.1002/adma.201802105 ↗
41. 10.1039/C5SC01733E10.1039/C5SC01733E ↗
42. 10.1039/C7MH00469A10.1039/C7MH00469A ↗
43. 10.1002/anie.20200907710.1002/anie.202009077 ↗
44. 10.1002/smll.20200090910.1002/smll.202000909 ↗
45. 10.1021/ja304986t10.1021/ja304986t ↗
46. 10.1002/adfm.20190179110.1002/adfm.201901791 ↗