Life and death agendas of actin filaments
Source abstract
Abstract
Cancer cells have now been shown to lack rigidity-sensing due to alteration in cytoskeletal sensor proteins, but can be reversed from a transformed to a rigidity-dependent growth state by the sensor proteins, resulting in restoration of contractility and adhesion.
The source flagged this abstract for review. Check formulas and completeness against the original publication.
Source: openaire · Quality: needs review · Source record ↗
Source flags: short_text
Source flags: short_text
Research context
OpenAlex topics: Cellular Mechanics and Interactions · Microtubule and mitosis dynamics · Cellular transport and secretion
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (11)
Show source-provided references
1. Yang, B. et al. Nat. Mater. https://doi.org/10.1038/s41563-019-0507-0 (2019).10.1038/s41563-019-0507-0 ↗
2. Wolfenson, H. et al. Nat. Cell Biol. 18, 33–42 (2016).10.1038/ncb3277 ↗
3. Farag, A. K. & Roh, E. J. Med. Res. Rev. 39, 349–385 (2019).10.1002/med.21518 ↗
4. Stehn, J. R., Schevzov, G., O’Neill, G. M. & Gunning, P. W. Curr. Cancer Drug Targets 6, 245–256 (2006).10.2174/156800906776842948 ↗
5. Hendricks, M. & Weintraub, H. Proc. Natl Acad. Sci. USA 78, 5633–5637 (1981).10.1073/pnas.78.9.5633 ↗
6. Gunning, P. W. & Hardeman, E. C. Curr. Biol. 27, R8–R13 (2017).10.1016/j.cub.2016.11.033 ↗
7. Pathan-Chhatbar, S. et al. J. Biol. Chem. 293, 863–875 (2018).10.1074/jbc.M117.806521 ↗
8. Sao, K. et al. Mol. Biol. Cell 30, 1170–1181 (2019).10.1091/mbc.E18-06-0355 ↗
9. Meiring, J. C. M. et al. Curr. Biol. 28, 2331–2337 (2018).10.1016/j.cub.2018.05.053 ↗
10. Meiring, J. C. M. et al. J. Cell Sci. 132, jcs228916 (2019).10.1242/jcs.228916 ↗
11. Desouza-Armstrong, M., Gunning, P. W. & Stehn, J. R. Cytoskeleton 74, 233–248 (2017).10.1002/cm.21367 ↗