Au Nanoparticles in 2D Bimetallic Metal–Organic Frameworks with Enhanced Plasmonic Nanozyme Activity for Antibacterial Therapy

In the past decade, nanozymes have attracted increasing attention owing to their unique advantages compared to natural enzymes, including high stability against denaturation, low production cost, and resistance to high concentrations of substrates. However, their real applications are limited due to their lower catalytical activity. Herein, we reported a nanozyme prepared by integrating two-dimensional (2D) bimetallic metal–organic frameworks (MOFs) with plasmonic Au nanoparticles (Au NPs). The localized surface plasmon resonance (LSPR) excitation and the charge transfer in bimetallic MOFs can dramatically improve the enzyme-like performance of nanozymes. Investigations of the factors that influence the enzyme-like activity showed the mechanism of the plasmonic hot carrier-activated Ni center of NiCo-MOFs enabling the improved nanozyme activity, and accelerated reaction kinetics is suggested. Based on the proposed mechanism, the performance of the plasmonic nanozyme toward antibacterial therapy was estimated. A significantly enhanced wound healing ability was observed. The present study provides a practical method for tailoring nanozyme activity toward enhanced catalytical performance.