Magnetic Resonance Imaging-Guided Focused Ultrasound-Based Delivery of Radiolabeled Copper Nanoclusters to Diffuse Intrinsic Pontine Glioma

Xiaohui Zhang; Dezhuang Ye; Lihua Yang; Yimei Yue; Deborah Sultan; Christopher Pham Pacia; Hannah Pang; Lisa Detering; Gyu Seong Heo; Hannah Luehmann; Ankur Choksi; Abhishek Sethi; David D. Limbrick; Oren J. Becher; Yuan-chuan Tai; Joshua B. Rubin; Hong Chen; Yongjian Liu

doi:10.1021/acsanm.0c02297

journal article·2020-11-25Open access

Magnetic Resonance Imaging-Guided Focused Ultrasound-Based Delivery of Radiolabeled Copper Nanoclusters to Diffuse Intrinsic Pontine Glioma

Xiaohui Zhang, Dezhuang Ye, Lihua Yang, Yimei Yue, Deborah Sultan, Christopher Pham Pacia, Hannah Pang, Lisa Detering, Gyu Seong Heo, Hannah Luehmann, Ankur Choksi, Abhishek Sethi, David D. Limbrick, Oren J. Becher, Yuan-chuan Tai, Joshua B. Rubin, Hong Chen, Yongjian Liu

ACS Applied Nano Materials· Volume 3· Issue 11

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Source abstract

Abstract

Diffuse intrinsic pontine glioma (DIPG) is an invasive pediatric brainstem malignancy exclusively in children without effective treatment due to the often-intact blood–brain tumor barrier (BBTB), an impediment to the delivery of therapeutics. Herein, we used focused ultrasound (FUS) to transiently open BBTB and delivered radiolabeled nanoclusters (64Cu-CuNCs) to tumors for positron emission tomography (PET) imaging and quantification in a mouse DIPG model. First, we optimized FUS acoustic pressure to open the blood–brain barrier (BBB) for the effective delivery of 64Cu-CuNCs to pons in wild-type mice. Then, the optimized FUS pressure was used to deliver radiolabeled agents in DIPG mouse. Magnetic resonance imaging (MRI)-guided FUS-induced BBTB opening was demonstrated using a low-molecular-weight, short-lived 68Ga-DOTA-ECL1i radiotracer and PET/CT before and after treatment. We then compared the delivery efficiency of 64Cu-CuNCs to DIPG tumor with and without FUS treatment and demonstrated the FUS-enhanced delivery and time-dependent diffusion of 64Cu-CuNCs within the tumor.

Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Ultrasound and Hyperthermia Applications · Nanoparticle-Based Drug Delivery · MRI in cancer diagnosis

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, United States

Department of Mechanical Engineering and Material Science, Washington University in St. Louis, St. Louis, Missouri 63130, United States

Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri 63110, United States

Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri 63130, United States

School of Medicine, University of Maryland, Baltimore, Maryland 21201, United States

Department of Neurosurgery, Washington University in St. Louis, St. Louis, Missouri 63110, United States

Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, United States

Department of Neuroscience, Washington University School of Medicine, St. Louis, Missouri 63110, United States

Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri 63108, United States

Funding

Children's Discovery Institute · National Institute of Biomedical Imaging and Bioengineering · National Institute of Mental Health

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