Lipid discovery for mRNA delivery guided by machine learning
Source abstract
Abstract
Combining machine learning with high-throughput synthesis expedites ionizable cationic lipid development for nanoparticle-based messenger RNA delivery.
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Source: openaire · Quality: needs review · Source record ↗
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Research context
OpenAlex topics: RNA Interference and Gene Delivery · Advanced biosensing and bioanalysis techniques · Virus-based gene therapy research
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References (10)
Show source-provided references
1. Kulkarni, J. A. et al. Nat. Nanotechnol. 16, 630–643 (2021).10.1038/s41565-021-00898-0 ↗
2. Akinc, A. et al. Nat. Biotechnol. 26, 561–569 (2008).10.1038/nbt1402 ↗
3. Semple, S. C. et al. Nat. Biotechnol. 28, 172–176 (2010).10.1038/nbt.1602 ↗
4. Jayaraman, M. et al. Angew. Chem. Int. Ed. 51, 8529–8533 (2012).10.1002/anie.201203263 ↗
5. Akinc, A. et al. Nat. Nanotechnol. 14, 1084–1087 (2019).10.1038/s41565-019-0591-y ↗
6. Hou, X., Zaks, T., Langer, R. & Dong, Y. Nat. Rev. Mater. 6, 1078–1094 (2021).10.1038/s41578-021-00358-0 ↗
7. Li, B. et al. Nat. Mater. https://doi.org/10.1038/s41563-024-01867-3 (2024).10.1038/s41563-024-01867-3 ↗
8. Cheng, Q. et al. Nat. Nanotechnol. 15, 313–320 (2020).10.1038/s41565-020-0669-6 ↗
9. Yamankurt, G. et al. Nat. Biomed. Eng. 3, 318–327 (2019).10.1038/s41551-019-0351-1 ↗
10. Reker, D. et al. Nat. Nanotechnol. 16, 725–733 (2021).10.1038/s41565-021-00870-y ↗