journal article·2013-11Open access

Translating materials design to the clinic

Jeffrey A. Hubbell, Robert Langer

Nature Materials· Volume 12· Issue 11

Abstract

Many materials-based therapeutic systems have reached the clinic or are in clinical trials. Here we describe materials design principles and the construction of delivery vehicles, as well as their adaptation and evaluation for human use.
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Source: openaire · Quality: needs review · Source record ↗
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Research context

OpenAlex topics: Nanoparticle-Based Drug Delivery · Graphene and Nanomaterials Applications · 3D Printing in Biomedical Research

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References (55)

Show source-provided references
1. Hubbell, J. A. & Chilkoti, A. Science 337, 303–305 (2012).10.1126/science.1219657 ↗
2. Petros, R. A. & DeSimone, J. M. Nature Rev. Drug Discov. 9, 615–627 (2010).10.1038/nrd2591 ↗
3. Yoo, J. W., Irvine, D. J., Discher, D. E. & Mitragotri, S. Nature Rev. Drug Discov. 10, 521–535 (2011).10.1038/nrd3499 ↗
4. Davis, M. E., Chen, Z. G. & Shin, D. M. Nature Rev. Drug Discov. 7, 771–782 (2008).10.1038/nrd2614 ↗
5. Wang, A. Z., Langer, R. & Farokhzad, O. C. Annu. Rev. Med. 63, 185–198 (2012).10.1146/annurev-med-040210-162544 ↗
6. Baish, J. W. et al. Proc. Natl Acad. Sci. USA 108, 1799–1803 (2011).10.1073/pnas.1018154108 ↗
7. Prabhakar, U. et al. Cancer Res. 73, 2412–2417 (2013).10.1158/0008-5472.CAN-12-4561 ↗
8. Hamaguchi, T. et al. Br. J. Cancer 92, 1240–1246 (2005).10.1038/sj.bjc.6602479 ↗
9. Hamaguchi, T. et al. Br. J. Cancer 97, 170–176 (2007).10.1038/sj.bjc.6603855 ↗
10. Kato, K. et al. Invest. New Drugs 30, 1621–1627 (2012).10.1007/s10637-011-9709-2 ↗
11. Cabral, H. et al. Nature Nanotech. 6, 815–823 (2011).10.1038/nnano.2011.166 ↗
12. Endo, K. et al. Cancer Sci. 104, 369–374 (2013).10.1111/cas.12079 ↗
13. Uchino, H. et al. Br. J. Cancer 93, 678–687 (2005).10.1038/sj.bjc.6602772 ↗
14. Plummer, R. et al. Br. J. Cancer 104, 593–598 (2011).10.1038/bjc.2011.6 ↗
15. Murakami, M. et al. Sci. Transl. Med. 3, 64ra62 (2011).10.1126/scitranslmed.3001385 ↗
16. Gref, R. et al. Science 263, 1600–1603 (1994).10.1126/science.8128245 ↗
17. Hrkach, J. et al. Sci. Transl. Med. 4, 128ra139 (2012).10.1126/scitranslmed.3003651 ↗
18. Von Maltzahn, G. et al. Nature Mater. 10, 545–552 (2011).10.1038/nmat3049 ↗
19. Murakami, M. et al. Cancer Res. 73, 4862–4871 (2013).10.1158/0008-5472.CAN-13-0062 ↗
20. Castanotto, D. & Rossi, J. J. Nature 457, 426–433 (2009).10.1038/nature07758 ↗
21. De Fougerolles, A., Vornlocher, H. P., Maraganore, J. & Lieberman, J. Nature Rev. Drug Discov. 6, 443–453 (2007).10.1038/nrd2310 ↗
22. Davis, M. E. Mol. Pharm. 6, 659–668 (2009).10.1021/mp900015y ↗
23. Boussif, O. et al. Proc. Natl Acad. Sci. USA 92, 7297–7301 (1995).10.1073/pnas.92.16.7297 ↗
24. Bartlett, D. W., Su, H., Hildebrandt, I. J., Weber, W. A. & Davis, M. E. Proc. Natl Acad. Sci. USA 104, 15549–15554 (2007).10.1073/pnas.0707461104 ↗
25. Rahman, M. A. et al. J. Control. Release 159, 384–392 (2012).10.1016/j.jconrel.2012.01.045 ↗
26. Davis, M. E. et al. Nature 464, 1067–1070 (2010).10.1038/nature08956 ↗
27. Akinc, A. et al. Nature Biotechnol. 26, 561–569 (2008).10.1038/nbt1402 ↗
28. Love, K. T. et al. Proc. Natl Acad. Sci. USA 107, 1864–1869 (2010).10.1073/pnas.0910603106 ↗
29. Sahay, G. et al. Nature Biotechnol. 31, 653–658 (2013).10.1038/nbt.2614 ↗
30. Lee, H. et al. Nature Nanotech. 7, 389–393 (2012).10.1038/nnano.2012.73 ↗
31. Padilla-Parra, S. et al. Proc Natl Acad Sci USA 109, 17627–17632 (2012).10.1073/pnas.1211714109 ↗
32. Convertine, A. J., Benoit, D. S., Duvall, C. L., Hoffman, A. S. & Stayton, P. S. J. Control. Release 133, 221–229 (2009).10.1016/j.jconrel.2008.10.004 ↗
33. Yin, X., Hoffman, A. S. & Stayton, P. S. Biomacromolecules 7, 1381–1385 (2006).10.1021/bm0507812 ↗
34. Lundy, B. B., Convertine, A., Miteva, M. & Stayton, P. S. Bioconjug. Chem. 24, 398–407 (2013).10.1021/bc300486k ↗
35. Manganiello, M. J., Cheng, C., Convertine, A. J., Bryers, J. D. & Stayton, P. S. Biomaterials 33, 2301–2309 (2012).10.1016/j.biomaterials.2011.11.019 ↗
36. McDaniel, J. R. et al. Angew. Chem. Int. Ed. 52, 1683–1687 (2013).10.1002/anie.201200899 ↗
37. MacKay, J. A. et al. Nature Mater. 8, 993–999 (2009).10.1038/nmat2569 ↗
38. McDaniel, J. R., Macewan, S. R., Dewhirst, M. & Chilkoti, A. J. Control. Release 159, 362–367 (2012).10.1016/j.jconrel.2012.02.030 ↗
39. Hassouneh, W., MacEwan, S. R. & Chilkoti, A. Methods Enzymol. 502, 215–237 (2012).10.1016/B978-0-12-416039-2.00024-0 ↗
40. Hirsch, L. R. et al. Proc. Natl Acad. Sci. USA 100, 13549–13554 (2003).10.1073/pnas.2232479100 ↗
41. Kennedy, L. C. et al. Small 7, 169–183 (2011).10.1002/smll.201000134 ↗
42. O'Neal, D. P., Hirsch, L. R., Halas, N. J., Payne, J. D. & West, J. L. Cancer Lett. 209, 171–176 (2004).10.1016/j.canlet.2004.02.004 ↗
43. Gobin, A. M., Watkins, E. M., Quevedo, E., Colvin, V. L. & West, J. L. Small 6, 745–752 (2010).10.1002/smll.200901557 ↗
44. Bernardi, R. J., Lowery, A. R., Thompson, P. A., Blaney, S. M. & West, J. L. J. Neurooncol. 86, 165–172 (2008).10.1007/s11060-007-9467-3 ↗
45. Day, E. S. et al. Int. J. Nanomedicine 5, 445–454 (2010).10.2147/IJN.S10881 ↗
46. Day, E. S. et al. Nanomedicine 7, 1133–1148 (2012).10.2217/nnm.11.189 ↗
47. Farra, R. et al. Sci. Transl. Med. 4, 122ra121 (2012).10.1126/scitranslmed.3003276 ↗
48. Dvir, T. et al. Nature Nanotech. 6, 720–725 (2011).10.1038/nnano.2011.160 ↗
49. Tian, B. et al. Nature Mater. 11, 986–994 (2012).10.1038/nmat3404 ↗
50. Hook, A. L. et al. Nature Biotechnol. 30, 868–875 (2012).10.1038/nbt.2316 ↗
51. Smith, R. S. et al. Sci. Transl. Med. 4, 153ra132 (2012).
52. Kourtis, I. C. et al. PLoS ONE 8, e61646 (2013).10.1371/journal.pone.0061646 ↗
53. Moon, J. J. et al. Nature Mater. 10, 243–251 (2011).10.1038/nmat2960 ↗
54. Nembrini, C. et al. Proc. Natl Acad. Sci. USA 108, E989–E997 (2011).10.1073/pnas.1104264108 ↗
55. Reddy, S. T. et al. Nature Biotechnol. 25, 1159–1164 (2007).10.1038/nbt1332 ↗