Heterogeneous silicon mesostructures for lipid-supported bioelectric interfaces
Source abstract
Abstract
Silicon-based materials have widespread application as biophysical tools and biomedical devices. Here we introduce a biocompatible and degradable mesostructured form of silicon with multi-scale structural and chemical heterogeneities. The material was synthesized using mesoporous silica as a template through a chemical vapour deposition process. It has an amorphous atomic structure, an ordered nanowire-based framework and random submicrometre voids, and shows an average Young's modulus that is 2-3 orders of magnitude smaller than that of single-crystalline silicon. In addition, we used the heterogeneous silicon mesostructures to design a lipid-bilayer-supported bioelectric interface that is remotely controlled and temporally transient, and that permits non-genetic and subcellular optical modulation of the electrophysiology dynamics in single dorsal root ganglia neurons. Our findings suggest that the biomimetic expansion of silicon into heterogeneous and deformable forms can open up opportunities in extracellular biomaterial or bioelectric systems.
Source: europepmc · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Neuroscience and Neural Engineering · Advanced Sensor and Energy Harvesting Materials · Silicon Nanostructures and Photoluminescence
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (50)
Show source-provided references
1. Leigh, C. Handbook of Porous Silicon 1st edn (Springer, 2014).
2. Sailor, M. J. Porous Silicon in Practice: Preparation, Characterization, and Applications (Wiley-VCH, 2012).
3. Kim, D.-H., Ghaffari, R., Lu, N. S. & Rogers, J. A. Flexible and stretchable electronics for biointegrated devices. Annu. Rev. Biomed. Eng. 14, 113–128 (2012).10.1146/annurev-bioeng-071811-150018 ↗
4. Tian, B. Z. & Lieber, C. M. Synthetic nanoelectronic probes for biological cells and tissues. Annu. Rev. Anal. Chem. 6, 31–51 (2013).10.1146/annurev-anchem-062012-092623 ↗
5. Cogan, S. F. Neural stimulation and recording electrodes. Annu. Rev. Biomed. Eng. 10, 275–309 (2008).10.1146/annurev.bioeng.10.061807.160518 ↗
6. Tasciotti, E. et al. Mesoporous silicon particles as a multistage delivery system for imaging and therapeutic applications. Nature Nanotech. 3, 151–157 (2008).10.1038/nnano.2008.34 ↗
7. Chiappini, C. et al. Biodegradable silicon nanoneedles delivering nucleic acids intracellularly induce localized in vivo neovascularization. Nature Mater. 14, 532–539 (2015).10.1038/nmat4249 ↗
8. Gu, L. et al. In vivo time-gated fluorescence imaging with biodegradable luminescent porous silicon nanoparticles. Nature Commun. 4, 2326 (2013).10.1038/ncomms3326 ↗
9. Kim, W., Ng, J. K., Kunitake, M. E., Conklin, B. R. & Yang, P. Interfacing silicon nanowires with mammalian cells. J. Am. Chem. Soc. 129, 7228–7229 (2007).10.1021/ja071456k ↗
10. Hwang, S.-W. et al. A physically transient form of silicon electronics. Science 337, 1640–1644 (2012).10.1126/science.1226325 ↗
11. Park, J.-H. et al. Biodegradable luminescent porous silicon nanoparticles for in vivo applications. Nature Mater. 8, 331–336 (2009).10.1038/nmat2398 ↗
12. Kim, D.-H. et al. Dissolvable films of silk fibroin for ultrathin conformal bio-integrated electronics. Nature Mater. 9, 511–517 (2010).10.1038/nmat2745 ↗
13. Liu, J. et al. Syringe-injectable electronics. Nature Nanotech. 10, 629–636 (2015).10.1038/nnano.2015.115 ↗
14. Zhang, A. Q. & Lieber, C. M. Nano-bioelectronics. Chem. Rev. 116, 215–257 (2016).10.1021/acs.chemrev.5b00608 ↗
15. Zimmerman, J. F. et al. Free-standing kinked silicon nanowires for probing inter- and intracellular force dynamics. Nano Lett. 15, 5492–5498 (2015).10.1021/acs.nanolett.5b01963 ↗
16. Wegst, U. G. K., Bai, H., Saiz, E., Tomsia, A. P. & Ritchie, R. O. Bioinspired structural materials. Nature Mater. 14, 23–36 (2015).10.1038/nmat4089 ↗
17. Chomski, E. & Ozin, G. A. Panoscopic silicon—a material for ‘all’ length scales. Adv. Mater. 12, 1071–1078 (2000).10.1002/1521-4095(200007)12:14<1071::AID-ADMA1071>3.0.CO;2-J ↗
18. Bao, Z. H. et al. Chemical reduction of three-dimensional silica micro-assemblies into microporous silicon replicas. Nature 446, 172–175 (2007).10.1038/nature05570 ↗
19. Dai, F. et al. Bottom-up synthesis of high surface area mesoporous crystalline silicon and evaluation of its hydrogen evolution performance. Nature Commun. 5, 3605 (2014).10.1038/ncomms4605 ↗
20. Hochbaum, A. I., Gargas, D., Hwang, Y. J. & Yang, P. Single crystalline mesoporous silicon nanowires. Nano Lett. 9, 3550–3554 (2009).10.1021/nl9017594 ↗
21. Qu, Y. et al. Electrically conductive and optically active porous silicon nanowires. Nano Lett. 9, 4539–4543 (2009).10.1021/nl903030h ↗
22. Li, X. & Bohn, P. W. Metal-assisted chemical etching in HF/H(2)O(2) produces porous silicon. Appl. Phys. Lett. 77, 2572–2574 (2000).10.1063/1.1319191 ↗
23. Gordon, L. M. et al. Amorphous intergranular phases control the properties of rodent tooth enamel. Science 347, 746–750 (2015).10.1126/science.1258950 ↗
24. Ott, H. C. et al. Perfusion-decellularized matrix: using nature’s platform to engineer a bioartificial heart. Nature Med. 14, 213–221 (2008).10.1038/nm1684 ↗
25. Gu, D. & Schuth, F. Synthesis of non-siliceous mesoporous oxides. Chem. Soc. Rev. 43, 313–344 (2014).10.1039/C3CS60155B ↗
26. Wan, Y., Yang, H. F. & Zhao, D. Y. “Host-guest” chemistry in the synthesis of ordered nonsiliceous mesoporous materials. Acc. Chem. Res. 39, 423–432 (2006).10.1021/ar050091a ↗
27. Arora, H. et al. Block copolymer self-assembly-directed single-crystal homo- and heteroepitaxial nanostructures. Science 330, 214–219 (2010).10.1126/science.1193369 ↗
28. Joo, S. H. et al. Ordered nanoporous arrays of carbon supporting high dispersions of platinum nanoparticles. Nature 412, 169–172 (2001).10.1038/35084046 ↗
29. Zhao, D. Y. et al. Triblock copolymer syntheses of mesoporous silica with periodic 50 to 300 angstrom pores. Science 279, 548–552 (1998).10.1126/science.279.5350.548 ↗
30. Richman, E. K., Kang, C. B., Brezesinski, T. & Tolbert, S. H. Ordered mesoporous silicon through magnesium reduction of polymer templated silica thin films. Nano Lett. 8, 3075–3079 (2008).10.1021/nl801759x ↗
31. Tanaka, K., Maruyama, E., Shimada, T. & Okamoto, H. Amorphous Silicon 1st edn (Wiley, 1999).
32. Freund, L. B. & Suresh, S. Thin Film Materials: Stress, Defect Formation and Surface Evolution 1st edn (Cambridge Univ. Press, 2009).
33. Imperor-Clerc, M., Davidson, P. & Davidson, A. Existence of a microporous corona around the mesopores of silica-based SBA-15 materials templated by triblock copolymers. J. Am. Chem. Soc. 122, 11925–11933 (2000).10.1021/ja002245h ↗
34. Minev, I. R. et al. Electronic dura mater for long-term multimodal neural interfaces. Science 347, 159–163 (2015).10.1126/science.1260318 ↗
35. Lanzani, G. Materials for bioelectronics: organic electronics meets biology. Nature Mater. 13, 775–776 (2014).10.1038/nmat4021 ↗
36. Gautieri, A., Vesentini, S., Redaelli, A. & Buehler, M. J. Hierarchical structure and nanomechanics of collagen microfibrils from the atomistic scale up. Nano Lett. 11, 757–766 (2011).10.1021/nl103943u ↗
37. Picas, L., Rico, F. & Scheuring, S. Direct measurement of the mechanical properties of lipid phases in supported bilayers. Biophys. J. 102, L1–L3 (2012).10.1016/j.bpj.2011.11.4001 ↗
38. Han, D. X., Lorentzen, J. D., Weinberg-Wolf, J., McNeil, L. E. & Wang, Q. Raman study of thin films of amorphous-to-microcrystalline silicon prepared by hot-wire chemical vapor deposition. J. Appl. Phys. 94, 2930–2936 (2003).10.1063/1.1598298 ↗
39. Li, L. et al. Multifunctionality of chiton biomineralized armor with an integrated visual system. Science 350, 952–956 (2015).10.1126/science.aad1246 ↗
40. Shapiro, M. G., Homma, K., Villarreal, S., Richter, C. P. & Bezanilla, F. Infrared light excites cells by changing their electrical capacitance. Nature Commun. 3, 736 (2012).10.1038/ncomms1742 ↗
41. Carvalho-de-Souza, J. L. et al. Photosensitivity of neurons enabled by cell-targeted gold nanoparticles. Neuron 86, 207–217 (2015).10.1016/j.neuron.2015.02.033 ↗
42. Sanders, A. W., Jeerage, K. M., Schwartz, C. L., Curtin, A. E. & Chiaramonti, A. N. Gold nanoparticle quantitation by whole cell tomography. ACS Nano 9, 11792–11799 (2015).10.1021/acsnano.5b03815 ↗
43. Liu, Y. et al. Dopamine-melanin colloidal nanospheres: an efficient near-infrared photothermal therapeutic agent for in vivo cancer therapy. Adv. Mater. 25, 1353–1359 (2013).10.1002/adma.201204683 ↗
44. Kaplan, D. T. et al. Subthreshold dynamics in periodically stimulated squid giant axons. Phys. Rev. Lett. 76, 4074–4077 (1996).10.1103/PhysRevLett.76.4074 ↗
45. Liu, Y., Ai, K. & Lu, L. Polydopamine and its derivative materials: synthesis and promising applications in energy, environmental, and biomedical fields. Chem. Rev. 114, 5057–5115 (2014).10.1021/cr400407a ↗
46. Pan, L. et al. Hierarchical nanostructured conducting polymer hydrogel with high electrochemical activity. Proc. Natl Acad. Sci. USA 109, 9287–9292 (2012).10.1073/pnas.1202636109 ↗
47. Ghezzi, D. et al. A hybrid bioorganic interface for neuronal photoactivation. Nature Commun. 2, 166 (2011).10.1038/ncomms1164 ↗
48. Tee, B. C. K. et al. A skin-inspired organic digital mechanoreceptor. Science 350, 313–316 (2015).10.1126/science.aaa9306 ↗
49. Tian, B. Z. et al. Macroporous nanowire nanoelectronic scaffolds for synthetic tissues. Nature Mater. 11, 986–994 (2012).10.1038/nmat3404 ↗
50. Karzbrun, E., Tayar, A. M., Noireaux, V. & Bar-Ziv, R. H. Programmable on-chip DNA compartments as artificial cells. Science 345, 829–832 (2014).10.1126/science.1255550 ↗