Hard-X-ray dark-field imaging using a grating interferometer
Source abstract
Abstract
Imaging with visible light today uses numerous contrast mechanisms, including bright- and dark-field contrast, phase-contrast schemes and confocal and fluorescence-based methods. X-ray imaging, on the other hand, has only recently seen the development of an analogous variety of contrast modalities. Although X-ray phase-contrast imaging could successfully be implemented at a relatively early stage with several techniques, dark-field imaging, or more generally scattering-based imaging, with hard X-rays and good signal-to-noise ratio, in practice still remains a challenging task even at highly brilliant synchrotron sources. In this letter, we report a new approach on the basis of a grating interferometer that can efficiently yield dark-field scatter images of high quality, even with conventional X-ray tube sources. Because the image contrast is formed through the mechanism of small-angle scattering, it provides complementary and otherwise inaccessible structural information about the specimen at the micrometre and submicrometre length scale. Our approach is fully compatible with conventional transmission radiography and a recently developed hard-X-ray phase-contrast imaging scheme. Applications to X-ray medical imaging, industrial non-destructive testing and security screening are discussed.
Source: europepmc · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Advanced X-ray Imaging Techniques · X-ray Spectroscopy and Fluorescence Analysis · Crystallography and Radiation Phenomena
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (30)
Show source-provided references
1. Murphy, D. B. Fundamentals of Light Microscopy and Electronic Imaging (Wiley, New York, 2001).
2. Bonse, U. & Hart, M. An X-ray interferometer with long separated interfering beam paths. Appl. Phys. Lett. 6, 155–156 (1965).10.1063/1.1754212 ↗
3. Davis, T. J., Gao, D., Gureyev, T. E., Stevenson, A. W. & Wilkins, A. W. Phase-contrast imaging of weakly absorbing materials using hard X-rays. Nature 373, 595–598 (1995).10.1038/373595a0 ↗
4. Ingal, V. N. & Beliaevskaya, E. A. X-ray plane-wave topography observation of the phase contrast from non-crystalline objects. J. Phys. D 28, 2314–2317 (1995).10.1088/0022-3727/28/11/012 ↗
5. Chapman, D. et al. Diffraction enhanced x-ray imaging. Phys. Med. Biol. 42, 2015–2025 (1997).10.1088/0031-9155/42/11/001 ↗
6. Snigirev, A., Snigireva, I., Kohn, V., Kuznetsov, S. & Schelokov, I. On the possibilities of X-ray phase contrast microimaging by coherent high-energy synchrotron radiation. Rev. Sci. Instrum. 66, 5486–5492 (1995).10.1063/1.1146073 ↗
7. Wilkins, S. W., Gureyev, T. E., Gao, D., Pogany, A. & Stevenson, A. W. Phase-contrast imaging using polychromatic hard X-rays. Nature 384, 335–337 (1996).10.1038/384335a0 ↗
8. Momose, A. Recent advances in X-ray phase imaging. Japan J. Appl. Phys. 44, 6355–6267 (2005).10.1143/JJAP.44.6355 ↗
9. Momose, A., Yashiro, W., Takeda, Y., Suzuki, Y. & Hattori, T. Phase tomography by X-ray Talbot interferometry for biological imaging. Japan J. Appl. Phys. 45, 5254–5262 (2006).10.1143/JJAP.45.5254 ↗
10. Weitkamp, T. et al. Quantitative X-ray phase imaging with a grating interferometer. Opt. Express 13, 6296–6304 (2005).10.1364/OPEX.13.006296 ↗
11. Pfeiffer, F., Weitkamp, T., Bunk, O. & David, C. Phase retrieval and differential phase-contrast imaging with low-brilliance X-ray sources. Nature Phys. 2, 258–261 (2006).10.1038/nphys265 ↗
12. Morrison, G. R. & Browne, M. T. Dark-field imaging with the scanning-transmission X-ray microscope. Rev. Sci. Instrum. 63, 611–614 (1992).10.1063/1.1143820 ↗
13. Chapman, H. N., Jacobsen, C. & Williams, S. A characterisation of dark-field imaging of colloidal gold labels in a scanning transmission X-ray microscope. Ultramicroscopy 62, 191–213 (1996).10.1016/0304-3991(96)00003-4 ↗
14. Suzuki, Y. & Uchida, F. Dark-field imaging in hard X-ray scanning microscopy. Rev. Sci. Instrum. 66, 1468–1470 (1995).10.1063/1.1145943 ↗
15. Pagot, E. et al. A method to extract quantitative information in analyzer-based X-ray phase contrast imaging. Appl. Phys. Lett. 82, 3421–3423 (2003).10.1063/1.1575508 ↗
16. Levine, L. E. & Long, G. G. X-ray imaging with ultra-small-angle X-ray scattering as a contrast mechanism. J. Appl. Cryst. 37, 757–765 (2004).10.1107/S0021889804016073 ↗
17. Ando, M. et al. Clinical step onward with X-ray dark-field imaging and perspective view of medical applications of synchrotron radiation in Japan. Nucl. Instrum. Methods A 548, 1–16 (2005).10.1016/j.nima.2005.03.059 ↗
18. Shimao, D., Sugiyama, H., Kunisada, T. & Ando, M. Articular cartilage depicted at optimized angular position of Laue angular analyzer by X-ray dark-field imaging. Appl. Radiat. Isot. 64, 868–874 (2006).10.1016/j.apradiso.2006.03.004 ↗
19. von Ardenne, M. Das Elektronen-Rastermikroskop. Z. Tech. Phys. 19, 407–416; Z. Phys. 109, 553–572 (1938).10.1007/BF01341584 ↗
20. Ramberg, E. G. Phase contrast in electron microscope images. J. Appl. Phys. 20, 441–444 (1949).10.1063/1.1698403 ↗
21. Lohmann, A. W. & Silva, D. E. An interferometer based on the Talbot effect. Opt. Commun. 2, 413–415 (1971).10.1016/0030-4018(71)90055-1 ↗
22. Yokozeki, S. & Suzuki, T. Shearing interferometer using grating as beam splitter. Appl. Opt. 10, 1575–1579 (1971).10.1364/AO.10.001575 ↗
23. Pfeiffer, F. et al. Shearing interferometer for quantifying the coherence of hard X-ray beams. Phys. Rev. Lett. 94, 164801 (2005).10.1103/PhysRevLett.94.164801 ↗
24. Weitkamp, T., David, C., Kottler, C., Bunk, O. & Pfeiffer, F. Tomography with grating interferometers at low-brilliance sources. SPIE Int. Soc. Opt. Eng. 6318, 28–32 (2006).
25. Harding, G. X-ray scatter tomography for explosives detection. Radiat. Phys. Chem. 71, 869–881 (2004).10.1016/j.radphyschem.2004.04.111 ↗
26. Harding, G. & Schreiber, B Coherent X-ray scatter imaging and its applications in biomedical science and industry. Radiat. Phys. Chem. 56, 229–245 (1999).10.1016/S0969-806X(99)00283-2 ↗
27. Fernandez, M. et al. Small-angle X-ray scattering studies of human breast tissue samples. Phys. Med. Biol. 47, 577–592 (2002).10.1088/0031-9155/47/4/303 ↗
28. Fernandez, M. et al. Human breast cancer in vitro: Matching histo-pathology with small-angle X-ray scattering and diffraction enhanced X-ray imaging. Phys. Med. Biol. 50, 2991–3006 (2005).10.1088/0031-9155/50/13/002 ↗
29. David, C. et al. Fabrication of diffraction gratings for hard X-ray phase contrast imaging. Microelectron. Eng. 84, 1172–1177 (2007).10.1016/j.mee.2007.01.151 ↗
30. Bech, M. et al. X-Ray imaging with the PILATUS 100K detector. Appl. Radiat. Isot. (2007, in the press) (doi:10.1016/j.apradiso.2007.10.003).10.1016/j.apradiso.2007.10.003 ↗