DataVXACS Applied Nano MaterialsPaper
journal article·2020-04-24Open access

Functionalization of a Few-Layer Antimonene with Oligonucleotides for DNA Sensing

Tania García-Mendiola, Cristina Gutiérrez-Sánchez, Carlos Gibaja, Iñigo Torres, Carlos Busó-Rogero, Felix Pariente, Jesús Solera, Zahra Razavifar, Juan J. Palacios, Félix Zamora, Encarnación Lorenzo

ACS Applied Nano Materials· Volume 3· Issue 4
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Source abstract

Abstract

Antimonene, a novel group 15 two-dimensional material, is functionalized with an oligonucleotide as a first step to DNA sensor development. The functionalization process leads to a few-layer antimonene modified with DNA that after deposition on gold screen-printed electrodes gives a simple and efficient DNA electrochemical sensing platform. We provide theoretical and experimental data of the DNA–antimonene interaction, confirming that oligonucleotides interact noncovalently but strongly with antimonene. The potential utility of this antimonene-based sensing device is assessed using, as a case of study, a sequence from the BRCA1 gene as the target DNA. The selectivity of the device allows not only recognition of a specific DNA sequence but also detection of a mutation in this gene associated with breast cancer, directly in clinical samples.
Source: openalex_inverted_index · Quality: baseline

Research context

NanomaterialsMaterials processing

OpenAlex topics: Molecular Junctions and Nanostructures · Advanced biosensing and bioanalysis techniques · Supramolecular Self-Assembly in Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Departamento de Química Analítica. Universidad Autónoma de Madrid, Madrid 28049, Spain

Institute for Advanced Research in Chemical Sciences, Universidad Autónoma de Madrid, Ciudad Universitaria de Cantoblanco, Madrid 28049, Spain

Departamento de Química Inorgánica. Universidad Autónoma de Madrid, Madrid 28049, Spain

IMDEA Nanociencia, Ciudad Universitaria de Cantoblanco, Madrid 28049, Spain

Molecular Oncogenetics Unit, La Paz Universitary Hospital, Biochemistry Department, Faculty of Medicine, Universidad Autónoma de Madrid, Madrid 28046, Spain

Department of Physics, Payame Noor University, Tehran 19395-3697, Iran

Departamento de Física de la Materia Condensada, Universidad Autónoma de Madrid, Madrid 28049, Spain

Condensed Matter Physics Institute, Universidad Autónoma de Madrid, Madrid 28049, Spain

Instituto Nicolás Cabrera, Universidad Autónoma de Madrid, Madrid 28049, Spain

Funding

Generalitat Valenciana · Comunidad de Madrid · Fundación Ramón Areces · Ministerio de Economía y Competitividad

References (40)

Show source-provided references
1. 10.1016/j.mattod.2016.10.00210.1016/j.mattod.2016.10.002 ↗
2. 10.1021/acs.chemrev.6b0055810.1021/acs.chemrev.6b00558 ↗
3. 10.1038/nmat184910.1038/nmat1849 ↗
4. 10.1088/2053-1583/1/2/02500110.1088/2053-1583/1/2/025001 ↗
5. 10.1002/adma.20160212810.1002/adma.201602128 ↗
6. 10.1002/anie.20160529810.1002/anie.201605298 ↗
7. 10.1039/C7CS00125H10.1039/C7CS00125H ↗
8. 10.1002/anie.20170298310.1002/anie.201702983 ↗
9. 10.1038/s41467-018-07947-810.1038/s41467-018-07947-8 ↗
10. 10.1039/C4CS00300D10.1039/C4CS00300D ↗
11. 10.1002/adma.20150242210.1002/adma.201502422 ↗
12. 10.1002/adma.20150630610.1002/adma.201506306 ↗
13. 10.1016/j.addr.2016.06.00110.1016/j.addr.2016.06.001 ↗
14. 10.1002/adfm.20160096110.1002/adfm.201600961 ↗
15. 10.1021/acs.analchem.6b0242210.1021/acs.analchem.6b02422 ↗
16. 10.1002/anie.20161051210.1002/anie.201610512 ↗
17. 10.1002/adma.20170377110.1002/adma.201703771 ↗
18. 10.1371/journal.pone.013672010.1371/journal.pone.0136720 ↗
19. 10.1021/acs.bioconjchem.6b0056710.1021/acs.bioconjchem.6b00567 ↗
20. 10.1038/s41598-019-41136-x10.1038/s41598-019-41136-x ↗
21. 10.1371/journal.pone.007238910.1371/journal.pone.0072389 ↗
22. 10.1021/acsnano.6b0606710.1021/acsnano.6b06067 ↗
23. 10.1002/adma.20160219310.1002/adma.201602193 ↗
24. 10.1016/j.biomaterials.2016.03.02210.1016/j.biomaterials.2016.03.022 ↗
25. 10.1002/aenm.20170260610.1002/aenm.201702606 ↗
26. 10.1155/2012/37867410.1155/2012/378674 ↗
27. 10.1039/c001062f10.1039/c001062f ↗
28. 10.1016/j.jphotobiol.2004.03.00510.1016/j.jphotobiol.2004.03.005 ↗
29. 10.1016/S0956-5663(98)00017-710.1016/S0956-5663(98)00017-7 ↗
30. 10.1016/j.bios.2005.10.02710.1016/j.bios.2005.10.027 ↗
31. 10.1016/j.bios.2008.07.00410.1016/j.bios.2008.07.004 ↗
32. 10.1016/S0022-2836(61)80047-810.1016/S0022-2836(61)80047-8 ↗
33. 10.1016/0006-3002(55)90261-410.1016/0006-3002(55)90261-4 ↗
34. Meehan T. · J. Biol. Chem. · 1982 · 257 · 1047910.1016/S0021-9258(18)34043-2 ↗
35. 10.1351/pac19916305071110.1351/pac199163050711 ↗
36. 10.1103/PhysRevA.38.309810.1103/PhysRevA.38.3098 ↗
37. 10.1103/PhysRevB.37.78510.1103/PhysRevB.37.785 ↗
38. 10.1063/1.44880010.1063/1.448800 ↗
39. 10.1103/PhysRevB.66.03532210.1103/PhysRevB.66.035322 ↗
40. 10.1063/1.352604410.1063/1.3526044 ↗