Au-Decorated N-Rich Carbon Dots as Peroxidase Mimics for the Detection of Acetylcholinesterase Activity

Dingding Zhang; Qingyi Han; Wendong Liu; Keying Xu; Mingzheng Shao; Yuyan Li; Peiyao Du; Zhen Zhang; Bingsi Liu; Libing Zhang; Xiaoquan Lu

doi:10.1021/acsanm.1c03613

journal article·2022-02-25

Au-Decorated N-Rich Carbon Dots as Peroxidase Mimics for the Detection of Acetylcholinesterase Activity

Dingding Zhang, Qingyi Han, Wendong Liu, Keying Xu, Mingzheng Shao, Yuyan Li, Peiyao Du, Zhen Zhang, Bingsi Liu, Libing Zhang, Xiaoquan Lu

ACS Applied Nano Materials· Volume 5· Issue 2

Publisher page

Source abstract

Abstract

Well-distributed metals anchored on supports have attracted great attention owing to their potential application as cost-effective catalysts. Here, we demonstrate the successful preparation of Au-decorated N-rich carbon dot (Au-CD) nanocomposites, which possess excellent stability in aqueous media. The Au-CDs exhibit remarkable peroxidase-mimicking activity and high affinity to the substrate due to the fast electron-transfer process and ligand-free surface. Based on this, an Au-CD nanozyme-based colorimetric biosensor was successfully developed to assess the activity of acetylcholinesterase with high sensitivity and selectivity. More importantly, an ideal performance was achieved in clinical serum analysis. This work paves the way for the development of well-distributed metals anchored on supports as nanozymes for sensing applications.

Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials Catalysis & surfaces

OpenAlex topics: Advanced Nanomaterials in Catalysis · Electrochemical sensors and biosensors · Carbon and Quantum Dots Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Tianjin Key Laboratory of Molecular Optoelectronic, Department of Chemistry, Tianjin University, Tianjin 300072, People’s Republic of China

Key Laboratory of Bioelectrochemistry and Environmental Analysis of Gansu Province, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, People’s Republic of China

Funding

National Natural Science Foundation of China · Peiyang Talents Project of Tianjin University · Program for Chang Jiang Scholars and Innovative Research Team, Ministry of Education · Special Fund Project for the Central Government to Guide Local Science and Technology Development · Program of Tianjin Science and Technology Major Project and Engineering

References (43)

Show source-provided references

1. 10.3390/ijms1506980910.3390/ijms15069809 ↗

2. 10.1016/j.snb.2016.09.04810.1016/j.snb.2016.09.048 ↗

3. 10.1016/j.snb.2020.12802310.1016/j.snb.2020.128023 ↗

4. 10.1016/j.snb.2017.06.13610.1016/j.snb.2017.06.136 ↗

5. 10.1021/ac990439d10.1021/ac990439d ↗

6. 10.1021/la803870v10.1021/la803870v ↗

7. 10.1016/j.bios.2020.11223210.1016/j.bios.2020.112232 ↗

8. 10.1016/j.mattod.2020.08.02010.1016/j.mattod.2020.08.020 ↗

9. 10.1021/jacs.0c0727310.1021/jacs.0c07273 ↗

10. 10.1039/d0sc03522j10.1039/d0sc03522j ↗

11. 10.1021/acs.accounts.9b0014010.1021/acs.accounts.9b00140 ↗

12. 10.1002/anie.20046064910.1002/anie.200460649 ↗

13. 10.1038/nnano.2007.26010.1038/nnano.2007.260 ↗

14. 10.1039/c1cc11943e10.1039/c1cc11943e ↗

15. 10.1021/acs.analchem.9b0433310.1021/acs.analchem.9b04333 ↗

16. 10.1007/s12274-016-1395-010.1007/s12274-016-1395-0 ↗

17. 10.1039/c6nr02730j10.1039/c6nr02730j ↗

18. 10.1007/s40820-020-00520-310.1007/s40820-020-00520-3 ↗

19. 10.1002/adma.20200517210.1002/adma.202005172 ↗

20. 10.1002/adma.20120441910.1002/adma.201204419 ↗

21. 10.1021/acs.analchem.9b0543710.1021/acs.analchem.9b05437 ↗

22. 10.1021/acs.analchem.8b0330010.1021/acs.analchem.8b03300 ↗

23. 10.1021/acs.analchem.8b0088510.1021/acs.analchem.8b00885 ↗

24. 10.1016/j.bios.2020.11288210.1016/j.bios.2020.112882 ↗

25. 10.1002/adma.20140510510.1002/adma.201405105 ↗

26. 10.1021/acscatal.7b0319010.1021/acscatal.7b03190 ↗

27. 10.1002/smll.20180168010.1002/smll.201801680 ↗

28. 10.1007/s10118-015-1574-610.1007/s10118-015-1574-6 ↗

29. 10.1088/1361-6528/aab93610.1088/1361-6528/aab936 ↗

30. 10.1021/acs.analchem.1c0072110.1021/acs.analchem.1c00721 ↗

31. 10.1021/nn301092210.1021/nn3010922 ↗

32. 10.1002/adma.20130619210.1002/adma.201306192 ↗

33. 10.1038/s41565-019-0373-610.1038/s41565-019-0373-6 ↗

34. 10.1039/c3nr04402e10.1039/c3nr04402e ↗

35. 10.1002/adfm.20200787710.1002/adfm.202007877 ↗

36. 10.1039/b207290d10.1039/b207290d ↗

37. 10.1038/s41467-017-02502-310.1038/s41467-017-02502-3 ↗

38. 10.1016/j.jfda.2014.01.00410.1016/j.jfda.2014.01.004 ↗

39. 10.1021/nn300291r10.1021/nn300291r ↗

40. 10.1021/acsami.9b2162110.1021/acsami.9b21621 ↗

41. 10.1016/j.snb.2017.12.11510.1016/j.snb.2017.12.115 ↗

42. 10.1039/c6ra01917j10.1039/c6ra01917j ↗

43. 10.1002/smll.20190310810.1002/smll.201903108 ↗